教育经历:
2010-2015，理学博士，化学生物学，北京大学
2006-2010，理学学士，化学，北京大学
工作经历:
2020.9-至今，研究员，北大清华生命科学联合中心
2020.9-至今，研究员，北京大学生命科学学院
2015.11-2020.8，博士后，芝加哥大学化学系荣誉奖励:
2022年，拜尔学者
2022年，北京大学博雅青年学者
2021年，億方学者
2021年，北京市科技新星执教课程:
生物化学与分子生物学研究前沿，本科生
现代生物学基础理论（上），研究生 本实验室致力于研究RNA修饰/非编码RNA (ncRNA)的分子调控机制和相关生物功能。我们运用表观遗传学，分子生物学，结合高通量测序等多种技术手段来探索RNA修饰/ncRNA对于染色质动态调控的新机制，以及相关调控通路在早期胚胎发育、干细胞命运决定，自身免疫疾病，癌症及衰老中的生物功能。
主要研究方向：
1. 拓展染色质RNA修饰参与调控染色质功能的新型分子调控机制；
2. 解析染色质RNA修饰-染色质互作及在早期胚胎发育，干细胞命运决定，衰老及相关疾病，自身免疫疾病和癌症发展等过程中的相关生物功能；
3. 建立RNA/RNA表观遗传修饰精准功能解析及生物大分子互作相关的研究体系。
At PKU:
1.Jia Shi#, Xiaoya Pei#, Jinmin Peng#, Chanyuan Wu#, Yulin Lv, Xiaoman Wang, Yangzhong Zhou, Xueting Yuan, Xingbei Dong, Shuang Zhou, Dong Xu, Jiuliang Zhao, Jun Liu, Jiao Huang, Bin Du, Chen Yao, Xiaofeng Zeng, Mengtao Li*, Houzao Chen*, Qian Wang*, Monocyte-macrophage dynamics as key in disparate lung and peripheral immune responses in severe anti-melanoma differentiation-associated gene 5-positive dermatomyositis-related interstitial lung disease, Clinical and translational medicine, 2025, 15(2), e70226.
2.Lei Yang#, Mingli Ma#, Yawei Gao*, Jun Liu*, Decoding N6-methyladenosine's dynamic role in stem cell fate and early embryo development: insights into RNA-chromatin interactions, Current opinion in genetics & development, 2025, 91:102311.
3.Moping Xu#, Xiaoyang Liu#, Miao Wang, Tingting Luo, Yawei Gao, Jun Liu*, Jiejun Shi*, BASAL: a universal mapping algorithm for nucleotide base-conversion sequencing, Nucleic Acids Research, 2025, 53(2).
4.Zihong Kang#, Ruimeng Li#, Chang Liu, Xiaozhe Dong, Yuxuan Hu, Lei Xu, Xinyu Liu, Yunfan Xiang, Liming Gao, Wenzhe Si, Lei Wang, Qing Li, Liang Zhang, Huan Wang, Xuerui Yang*, Jun Liu*, m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells, Cell, 2024, 187(21), 6035-6054.
5.Chang Liu#, Xiaoyang Dou#, Yutao Zhao#, Linda Zhang, Lisheng Zhang, Qing Dai, Jun Liu, Tong Wu, Yu Xiao, Chuan He*, IGF2BP3 promotes mRNA degradation through internal m7G modification, Nature communications, 2024, 15(1), 7421.
6.Yini Li#, Xiaoyang Dou#, Jun Liu#, Yu Xiao#, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W Ostrow, Chuan He*, Shuying Sun*, Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration, Nature Neurosciences, 2023, 26(8): 1328-1338.
7.Xiaoyang Dou#, Lulu Huang#, Yu Xiao#, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He*, Jun Liu*, METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity, Protein & Cell, 2023, pwad009.
8.Xiaoyang Dou#, Yu Xiao#, Chao Shen#, Kitty Wang#, Tong Wu, Chang Liu, Yini Li, Xianbin Yu, Jun Liu, Qing Dai, Kinga Pajdzik, Chang Ye, Ruiqi Ge, Boyang Gao, Jianhua Yu, Shuying Sun, Mengjie Chen*, Jianjun Chen*, Chuan He*, RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation, Nature Cell Biology, 2023, 25, 1359-1368.
9.高纯纯, 管敏鑫*, 何晓, 金昊, 金勇丰*, 刘君*, 罗慧, 曲慧儒, 谢珊珊, 杨运桂*, 张锐*, 张薪泞, 张艺凡, 周天华*. RNA修饰与人类疾病研究进展[J]. 中国科学:生命科学, 2023, 53 (11): 1502-1526.
10.Jiangbo Wei#, Xianbin Yu#, Lei Yang# , Xuelian Liu#, Boyang Gao, Boxian Huang, Xiaoyang Dou, Jun Liu, Zhongyu Zou, Xiao-Long Cui, Li-Sheng Zhang, Xingsen Zhao, Qinzhe Liu, P Cody He, Caraline Sepich-Poore, Nicole Zhong, Wenqiang Liu, Yanhe Li, Xiaochen Kou, Yanhong Zhao, You Wu, Xuejun Cheng, Chuan Chen, Yiming An, Xueyang Dong, Huanyu Wang, Qiang Shu, Ziyang Hao, Tao Duan, Yu-Ying He, Xuekun Li, Shaorong Gao*, Yawei Gao*, Chuan He*, FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science, 2022, 376(6596), 968–973.
11.Lihui Dong#, Chuanyuan Chen#, Yawei Zhang#, Peijin Guo, Zhenghang Wang, Jian Li, Yi Liu, Jun Liu, Renbao Chang, Yilin Li, Guanghao Liang, Weiyi Lai, Mengxue Sun, Urszula Dougherty, Marc B Bissonnette, Hailin Wang, Lin Shen, Meng Michelle Xu*, Dali Han*, The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth, Cancer Cell, 2021, 39(7): 945-957.
12.Yi Liu#, Guanghao Liang#, Hongjiao Xu#, Wenxin Dong#, Ze Dong#, Zhiwei Qiu, Zihao Zhang, Fangle Li, Yue Huang, Yilin Li, Jun Wu, Shenyi Yin, Yawei Zhang, Peijin Guo, Jun Liu, Jianzhong Jeff Xi, Peng Jiang, Dali Han*, Caiguang Yang*, Meng Michelle Xu*, Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metabolism, 2021, 33(6): 1221-1233.
13.Jiyu Tong#, Xuefei Wang#, Yongbo Liu#, Xingxing Ren#, Anmin Wang, Zonggui Chen, Jiameng Yao, Kaiqiong Mao, Tingting Liu, Feilong Meng, Wen Pan, Qiong Zou, Jun Liu, Yu Zhou, Qiang Xia, Richard A Flavell, Shu Zhu, Huabing Li, Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation, Science Advance, 2021, 7(18): eabd4742.
14.Chuan Chen#, Wenqiang Liu#, Jiayin Guo, Yuanyuan Liu, Xuelian Liu, Jun Liu, Xiaoyang Dou, Rongrong Le, Yaxin Huang, Chong Li, Lingyue Yang, Xiaochen Kou, Yanhong Zhao, You Wu, Jiayu Chen, Hong Wang, Bin Shen*, Yawei Gao*, Shaorong Gao*, Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos, Protein&Cell, 2021, 12(6), 455-474.
Before PKU:
1.Piroon Jenjaroenpun, Thidathip Wongsurawat, Taylor D Wadley, Trudy M Wassenaar, Jun Liu, Qing Dai, Visanu Wanchai, Nisreen S Akel, Azemat Jamshidi-Parsian, Aime T Franco, Gunnar Boysen, Michael L Jennings, David W Ussery, Chuan He, Intawat Nookaew, Decoding the epitranscriptional landscape from native RNA sequences, Nucleic Acids Res, 2021, 49, e7.
2.Jun Liu#, Xiaoyang Dou#, Chuanyuan Chen#, Chuan Chen, Chang Liu, Meng Michelle Xu, Siqi Zhao, Bin Shen, Yawei Gao*, Dali Han*, Chuan He*, N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription, Science, 2020, 367(6477): 580-586.
3.Min Wang#, Jun Liu#, Yan Zhao#, Ruizhi He#, Xiaodong Xu#, Xingjun Guo, Xu Li, Simiao Xu, Ji Miao, Jianpin Guo, Hang Zhang, Jun Gong, Feng Zhu, Rui Tian, Chengjian Shi, Feng Peng, Yechen Feng, Shuo Yu, Yu Xie, Jianxin Jiang, Min Li*, Wenyi Wei*, Chuan He*, Renyi Qin*, Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer, Molecular Cancer, 2020, 19(130).
4.Chang Liu#, Xiaolong Cui#, Boxuan Simen Zhao#, Pradnya Narkhede, Yawei Gao, Jun Liu, Xiaoyang Dou, Qing Dai, Li-Sheng Zhang, Chuan He, DNA 5‑methylcytosine-specific amplification and sequencing, Journal of the American Chemical Society, 2020, 142(10): 4539-4543.
5.Dali Han#*, Jun Liu#, Chuanyuan Chen, Lihui Dong, Yi Liu, Renbao Chang, Xiaona Huang, Yuanyuan Liu, Jianying Wang, Urszula Dougherty, Marc B Bissonnette, Bin Shen, Ralph R Weichselbaum, Meng Michelle Xu*, Chuan He*, Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells, Nature, 2019, 566(7743): 270-274.
6.Jiajie Hou#*, He Zhang#, Jun Liu#, Zhenjun Zhao, Jianye Wang, Zhike Lu, Bian Hu, Jiankui Zhou, Zhicong Zhao, Mingxuan Feng, Haiyan Zhang, Bin Shen, Xingxu Huang, Beicheng Sun, Chuan He*, Qiang Xia*, YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma, Molecular Cancer, 2019, 18(163).
7.Jun Liu#, Guanzheng Luo#, Juan Sun, Lili Men, Honggang Ye, Chuan He, Decheng Ren*, METTL14 is essential for β-cell survival and insulin secretion, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019, 1865(9): 2138-2148.
8.Jun Liu#, Bryan T Harada#, Chuan He, Regulation of gene expression by N6-methyladenosine in cancer, Trends in Cell Biology, 2019, 29(6): 487-499.
9.Siming Zhao, Jun Liu, Pranav Nanga, Yuwen Liu, A. Ercument Cicek, Nicholas Knoblauch, Chuan He, Matthew Stephens*, Xin He*, Detailed modeling of positive selection improves detection of cancer driver genes, Nature Communications, 2019, 10(3399).
10.Huilin Huang#, Hengyou Weng#, Keren Zhou#, Tong Wu#, Boxuan Simen Zhao#, Mingli Sun, Zhenhua Chen, Xiaolan Deng, Gang Xiao, Franziska Auer, Lars Klemm, Huizhe Wu, Zhixiang Zuo, Xi Qin, Yunzhu Dong, Yile Zhou, Hanjun Qin, Shu Tao, Juan Du, Jun Liu, Zhike Lu, Hang Yin, Ana Mesquita, Celvie L. Yuan, Yueh-Chiang Hu, Wenju Sun, Rui Su, Lei Dong, Chao Shen, Chenying Li, Ying Qing, Xi Jiang, Xiwei Wu, Miao Sun, Jun-Lin Guan, Lianghu Qu, Minjie Wei, Markus Müschen, Gang Huang*, Chuan He*, Jianhua Yang*, Jianjun Chen*, Histone H3 trimethylation at lysine 36 guides m6A RNA modification cotranscriptionally, Nature, 2019, 567(7748): 414-419.
11.Xiao Zhang#, Lian-Huan Wei#, Yuxin Wang#, Yu Xiao#, Jun Liu, Wei Zhang, Ning Yan, Gubu Amu, Xinjing Tang, Liang Zhang*, Guifang Jia*, Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates, Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(8): 2919-2924.
12.Jun Liu#, Mark A Eckert#, Bryan T Harada#, Song-Mei Liu#, Zhike Lu, Kangkang Yu, Samantha M Tienda, Agnieszka Chryplewicz, Allen C Zhu, Ying Yang, Jing-Tao Huang, Shao-Min Chen, Zhi-Gao Xu, Xiao-Hua Leng, Xue-Chen Yu, Jie Cao, Zezhou Zhang, Jianzhao Liu, Ernst Lengyel*, Chuan He*, m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer, Nature Cell Biology, 2018, 20(9): 1074-1083.
13.Yanan Yue#, Jun Liu#, Xiaolong Cui#, Jie Cao#, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He*, Jianzhao Liu*, VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation, Cell Discovery, 2018, 4(10).
14.Jun Liu, Guifang Jia, Methylation modifications in eukaryotic messenger RNA, Journal of Genetics and Genomics, 2014, 41(1): 21-33.
15.Guan-Zheng Luo#, Alice MacQueen#, Guanqun Zheng#, Hongchao Duan, Louis C. Dore, Zhike Lu, Jun Liu, Kai Chen, Guifang Jia*, Joy Bergelson*, Chuan He*, Unique features of the m6A methylome in Arabidopsis thaliana, Nature Communications, 2014, 5(5630).
16.Jun Liu, Jason Karpus, Seraphine V Wegner, Peng R Chen*, Chuan He*, Genetically encoded copper(I) reporters with improved response for use in imaging, Journal of the American Chemical Society, 2013, 135(8): 3144-3149.
17.Haiyun Gan#, Lu Wen#, Shangying Liao#, Xiwen Lin, Tingting Ma, Jun Liu, Chun-xiao Song, Min Wang, Chuan He, Chunsheng Han*, Fuchou Tang*, Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis, Nature Communications, 2013, 4(1995).
18.Guanqun Zheng#, John Arne Dahl#, Yamei Niu#, Peter Fedorcsak, Chun-Min Huang, Charles J. Li, Cathrine B. Vågbø, Yue Shi, Wen-Ling Wang, Shu-Hui ong, Zhike Lu, Ralph P.G. Bosmans, Qing Dai, Ya-Juan Hao, Xin Yang, Wen-Ming Zhao, Wei-Min Tong, Xiu-Jie Wang, Florian Bogdan, Kari Furu, Ye Fu, Guifang Jia, Xu Zhao, Jun Liu, Hans E. Krokan, Arne Klungland*, Yun-Gui Yang*, Chuan He*, ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility, Molecular Cell, 2013, 49(1): 18-29.
19.Meng Zhang#, Shixian Lin#, Xinwen Song, Jun Liu, Ye Fu, Xi Ge, Xinmiao Fu, Zengyi Chang*, Peng R Chen*, A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance, Nature Chemical Biology, 2011, 7(10): 671-677.
20.Yan Qiao, Yiyang Lin, Yijie Wang, Zhiyi Yang, Jun Liu, Jiang Zhou, Yun Yan, Jianbin Huang, Metal-driven hierarchical self-assembled one-dimensional nanohelices, Nano Letter, 2009, 9(12): 4500-4.
(#co-authors contributed equally, *Corresponding authors)
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