面试Seminar
题目：From sensation to action: deconstruct the neural circuit underlying a tactile decision in mice
报告人: Zengcai GUO, Ph.D.
Howard Hughes Medical Institute‟s Janelia Farm Research Campus
时间: 15:00pm, June 26th, 2014
地点: Rm. 411, New Life Sciences Building
Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? We delineate when and how activity in specific areas drives a whisker-based decision in mice. We first developed a decision task with ashort-term memory component that temporally separated tactile “sensation” and “action”. Using optogenetic inhibition by stimulating GABAergic neurons, we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making.
欢迎各位老师和同学积极参加！