学术报告
题目：The structure, function and neutralization of the human immunodeficiency virus (HIV-1) envelope glycoproteins
报告人：Joseph Sodroski
Professor
Microbiology and Immunobiology
Harvard Medical School
时间：2013年1月7日（周二）下午13:00-14:00 PM
地点：生命科学学院101报告厅
主持人：生命科学联合中心，欧阳颀
The major interests of the laboratory are the early events in human immunodeficiency virus (HIV-1) infection. Understanding and blocking these early events are critical to interrupting HIV-1 transmission and changing the course of the global AIDS pandemic. The laboratory studies HIV-1 entry into cells, a process that is mediated by the viral envelope glycoproteins. These glycoproteins bind receptors on the target cell and fuse viral and cell membranes. The laboratory is devoted to understanding this process at the molecular level, and identifying and characterizing inhibitors. The interaction of neutralizing antibodies with the HIV-1 envelope glycoproteins is being studied.
The laboratory is also investigating the molecular events involved in the uncoating of the HIV-1 capsid following the entry of the virus into the host cell. In some mammalian species, tripartite motif (TRIM) proteins have evolved to recognize retroviral capsids and block virus infection. The molecular basis for this novel form of innate intracellular immunity is being pursued.
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