生命科学联合中心学术报告
题目：Regulating the Timing of Genome Replication.
报告人：Nicholas Ridley Rhind, Ph.D.
Associate Professor, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
时间：2013-11-25（周一），13:00-14:00pm
地点：北京大学新生物楼邓祐才报告厅
联系人：生命科学联合中心，孔道春（电话：62760866）
Eukaryotic genomes replicate in define patterns with some origins in the genome firing early in S phase and others firing later. Replication timing correlates with transcription, chromatin modification, sub-nuclear localization and genome evolution, suggesting an intimate association between replication timing and other important aspects of chromosome metabolism. Based on an analytical model of genome-wide yeast replication kinetics, we propose that global replication timing is regulated by simple rules that effect the local probability of stochastic origin firing. Specifically, we propose that the probability of origin firing is governed by competition between origins for rate-limiting activators, and that the effectiveness with which origins compete is determined by an combination of the number of MCM complexes loaded at an origin (MCM being the replicative helicase and target of the activators) and the chromatin-regulated accessibly of MCM complexes to the activators. I will discuss the theoretical motivation for the model and our biochemical validation of it.
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