生命科学联合中心学术报告
题目：Nature as Stereochemist: Unraveling the complexities of polyketide antibiotic biosynthesis.
报告人：David Cane, Ph.D.
Professor, Department of Chemistry, Brown University, USA
时间：2013-11-11（周一），13:00-14:00pm
地点：北京大学新生物楼邓祐才报告厅
联系人：生命科学联合中心，陈鹏（6275-5773）
Polyketides, which are produced by Streptomyces and other Actinomycetes and which display a wealth of useful antibiotic, antitumor, and immunosuppressive activities, are notable for their intricate structures and stereochemical complexity. The majority of such polyketides are biosynthesized under the control of modular polyketide synthases (PKSs), multisubunit mega-enzymes in which each protein module is responsible for a single round of polyketide chain elongation and b-carbon modification, under control of proteins closely related in structure and mechanism to the well-characterized enzymes of fatty acid biosynthesis. The organization, number and domain composition of the individual PKS modules are a major determinant of the structure and stereochemistry of the eventually formed macrolide. At the same time, the individual catalytic domains are responsible for the strict stereochemical control required to elaborate the characteristic pattern of methyl and hydroxyl substitution and stereochemistry. We have devised sensitive and robust methods to probe the stereospecificity of individual polyketide synthase domains with the objective of unraveling their precise roles in the elaboration of complex polyketides.
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