学术报告
题目：Control of Chromatin-Dependent Transcription–Lessons from p53, AP-1, Brd4, and HPV
报告人：Cheng-Ming Chiang, Ph.D.
Professor of Biochemistry and Pharmacology
Simmons Comprehensive Cancer Center, Bldg. ND2.210H
University of Texas Southwestern Medical Center
时间：2013年8月20日（周二），16:00-17:00 PM
地点：生命科学学院311会议室
Transcription in higher eukaryotes is controlled by an array of transcription factors, including the general transcription machinery, general cofactors, and gene-specific activators and repressors. The complexity of gene regulation is further conferred by the existence of multiple protein family members recognizing consensus or non-canonical DNA-binding sequences. The chromatin structure in the human genome and posttranslational modification on protein molecules provide an additional level of control in modulating gene activity. In this lecture, I will review these control mechanisms using human papillomavirus (HPV) E6 and E2 proteins as examples to illustrate how DNA tumor virus-encoded transcriptional regulators are able to reprogram cellular activities by targeting p53 tumor suppressor protein and activator protein-1 (AP-1), respectively, via recruitment of distinct coregulators, such as p300 histone acetyl transferase and the chromatin adaptor bromodomain-containing protein 4 (Brd4). The interplay among these viral and cellular proteins and the crosstalk between different posttranslational modifications regulate gene activity in response to various environmental stresses.
联系人：李晴（电话：62752516）
欢迎各位老师和同学积极参加！