学术报告
题目：Microfluidics and Directed Cell Migration
报告人： Dr. Francis Lin
Department of Physics and Astronomy, University of Manitoba
报告时间：2012年11月20日（星期二）下午13:00
报告地点：北京大学定量生物学中心（原理论生物学中心）老化学楼东配楼102会议室（理教路西/老光华楼北侧）
摘要:
Cell migration underlies many physiological processes ranging from host defense to wound healing and to cancer metastasis. Diverse environmental factors such as chemical gradients and electric fields can guide the migration and trafficking of various cell types in tissues. Rapid development of microfluidics provides powerful quantitative test bed for cell migration analysis in controlled cellular microenvironments. Toward leveraging microfluidics-based approaches to directed cell migration research, we use microfluidic devices to study chemotactic and electrotactic migration of various cell types. Ongoing research in this direction includes experimental and modeling studies of CCR7-based combinatorial guidance for T cell trafficking in secondary lymphoid tissues, chemotaxis and electrotaxis of lymphocytes, breast cancer cells and adipose-derived stem cells. In addition to fundamental research, we develop integrated and easy-to-use microfluidic cell migration analysis system to explore its practical use for life science research and for clinical applications. An overview of the microfluidic cell migration research program at the University of Manitoba in Canada is provided in this talk.
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