学术报告
题目：Development of Biological Markers for Alzheimer`s Disease
报告人：Harald Hampel
Chair & Head of Department of Psychiatry,
University of Frankfurt, Germany
时间：2012年10月25日（周四），下午14:00-15:30 PM
地点：生命科学学院411会议室
Introduction:
The aim of this presentation is to stimulate radical shifts thinking and foster further discussion on the effective discovery-development-validation-qualification process of biological markers derived from all available technical modalities that meet the complex conceptual and pathophysiological challenges across all stages of the most prevalent, complex, non-linear, dynamic and chronically progressive sporadic Alzheimer`s disease (AD).
This talk evaluates the current state of the science regarding a broad spectrum of hypothesis-driven and exploratory technologies and ‘markers` as candidates for all required biomarker functions, in particular surrogate indicators of adaptive to maladaptive and compensatory to decompensatory, reversible to irreversible brain ‘systems failure`. I stress the future importance of the systems biology (SB) paradigm (next to the neural network paradigm) for substantial progress in AD research. SB represents an integrated and deeper investigation of interacting biomolecules within cells and organisms. This approach has only recently become feasible as high-throughput technologies, mass spectrometric analyses of proteins and lipids together with rigorous bioinformatics have evolved. Existing high-content data derived from clinically and experimentally derived neural tissues point to convergent pathophysiological pathways during the course of AD, transcending traditional descriptive studies to reach a more integrated and comprehensive understanding of AD pathophysiology, derived systems biomarkers and "druggable" system nodes.
Key-References & Resources
1. Biomarkers for Alzheimer`s disease: academic, industry and regulatory perspectives. Hampel, H. et al. Nature Reviews Drug Discovery. 9, 560–574 (2010).
2. Blennow, K., Hampel, H., Weiner, M., Zetterberg, H. Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nature Reviews Neurology. 2010; 6(3):131-44.
3. Hampel, H., Lista S. From Dominantly Inherited to Sporadic Alzheimer`s Disease: Crossing the Golden Biomarker Bridge? Nature Reviews Neurology. 2012; in press
4. Hampel, H. Lista S., Khachaturian, Z.S. Development of biomarkers to chart all Alzheimer`s disease stages: The royal road to cutting the therapeutic Gordian Knot. Alzheimer`s & Dementia 8, 312–336 (2012).
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