题  目: Condensate Formation, Oscillations and Genetic Resonance in Cell Dynamics
报告人: Mogens H. Jensen
Member of the Royal Danish Academy of Science and Letters
Professor of Complex Systems and Biophysics, dr. scient. (D.Sc.), Niels Bohr Institute, University of Copenhagen

时  间: 9月21日（周一）13:00-14:00
地  点: 吕志和楼B101
主持人: 李志远

摘  要:
When cells are damaged or stressed, they often respond by oscillating protein densities. We show that liquid-liquid phase separations lead to condensates of repair proteins around damage sites which occur in an oscillating fashion thus preventing that one condensate will dominate. The period of oscillations provides an optimal time scale for the repair mechanism [1]. By applying an external periodic protein signal, the internal oscillation can lock to the external signal which provides an optimal way to perform gene control [2,3]. The locking occurs when the ratio between the two frequencies is a rational number leading to Arnold tongues. If tongues overlap, chaotic dynamics may appear [2]. If the cells are not stressed or damaged, we may again apply an external periodic signal that couples to the internal damped protein oscillator which leads to non-linear resonance phenomena in the genetic response [4]. The findings are supported by experimental data from our collaborative groups at Harvard Medical School, Beijing/Shenzhen and Taipei.

[1] M.S. Heltberg, A. Lucchetti, F.-S. Hsieh, D.P.M. Nguyen, S.-h.Chen and Mogens H. Jensen, “Enhanced DNA repair through droplet formation and p53 oscillations”, Cell 185, 4394–4408 (2022).
[2] A. Jimenez, A. Lucchetti, M.S. Heltberg, L. Moretto, C. Sanchez, A. Jambhekar, G. Lahav and M.H. Jensen, “Entrainment and multi-stability of the p53 oscillator in human cells”, Cell Systems 15, 956-968 (2024).
[3] M.S. Heltberg, Y. Jiang, Y. Fan, Z. Zhang, M.S. Nordentoft, W. Lin, L. Qian, Q. Ouyang, Mogens H. Jensen and P. Wei, “Coupled oscillator cooperativity as a control mechanism in chronobiology”, Cell Systems, 14, 382-391 (2023).
[4] M.S. Heltberg, A. Jimenez, G. Lahav and M.H. Jensen, “Genetic Resonance in the p53 Signaling Network”, Cell Systems 17,101514 (2026).

报告人简介：

Mogens H. Jensen received his PhD from the University of Copenhagen in 1984. After that he went to The University of Chicago as a postdoc working with Leo Kadanoff. In 1997 he became full professor at the Niels Bohr Institute, the University of Copenhagen. He has worked on a long list of research topics in complex systems and biophysics, such as chaos theory, turbulence, protein oscillations, condensate formation, DNA-repair, genetic resonance. In 2011 he became secretary general of the Royal Danish Academy of Sciences and subsequently President of the Royal Academy in 2016. He has received several honors and prizes, most notably the Physics Prize of Norway, handed over by King Harald V in 2011. He was knighted by Queen Margrethe of Denmark in 2017 and subsequently knighted to first degree in 2020.