题目：DNA repair and genomic instability in cancer development and therapy.

报告人：JEAN GAUTIER, Ph.D.

Professor, Department of Genetics and Development

Columbia University

时间：2014-11-6（周四），13:00-14:00pm

地点：北京大学综合科研楼137会议室

联系人：生命科学联合中心， 孔道春

Most, if not all tumor cells harbor signs of genomic instability, which can contribute to their development. DNA repair is a powerful tumor suppressor mechanism and failure to repair DNA damage causes or facilitates tumor development. Nonetheless, DNA damaging therapies are amongst the most widely used and most successful cancer therapies. The inherent genomic instability of cancer cells makes them more vulnerable to a high damage burden. This can be exploited in the clinic by targeting specific DNA repair modules that are uniquely essential for tumor cells. I will discuss our studies on oncogene-driven genomic instability focusing on the MYC oncogene. I will also review our work on DNA repair of lesions arising from DNA damaging chemotherapies, namely drugs that generate DNA inter-strand crosslinks and DNA topoisomerase inhibitors.