生命科学联合中心学术报告
题目：Understanding Histone Methylation in Gene Regulation, Differentiation, and Oncogenesis.
报告人：G. Greg Wang，Ph.D.
Assistant Professor, Department of Biochemistry & Biophysics and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC
时间：2013-9-16（周一），13:00-14:00pm
地点：北京大学新生物楼邓祐才报告厅
主持人：生命科学联合中心，徐成冉
Covalent histone modifications including site-specific methylation, acetylation, phosphorylation and ubiquitination, constitute a hypothetical `epigenetic code` or `histone code`, which regulates various biological outputs such as gene transcription and DNA damage repair. It has been increasingly appreciated that both genetic and epigenetic aberrations contribute to the initiation and development of human cancers. My work focuses on the role of proteins that bind to histone methylations, termed histone methylation “effectors or readers”, in interpreting the meaning of histone methylation among different biological contexts, including differentiation or pathogenic conditions (especially cancer). I cover recent works on identification and characterization of novel effectors of trimethylation of histone H3, lysine 4 (H3K4Me3) and trimethylation of histone H3, lysine 36 (H3K36Me3). These studies underscore the critical role of histone methylation in regulating gene expression, as well as cellular and epigenetic states.
欢迎各位老师和同学积极参加！