学术报告
题目：Unraveling the mitochondrial surveillance pathway: a matter of life and death
报告人：Ying Liu, Ph.D
Massachusetts General Hospital & Harvard Medical School
时间：3月28日 (周四) 2:00‐3:30 PM
地点：生命科学学院411会议室
As the cellular power house, mitochondria provide energy to sustain the life of the cell. They are also sites of calcium storage and are involved in numerous signaling pathways. The proper function of mitochondria is actively challenged by intrinsic metabolic byproducts (eg. ROS), or by extrinsic pathogens and xenobiotics. The resulting dysfunction of mitochondria has been implicated in aging and numerous diseases such as cardiac dysfunction, neurodegenerative disorders and cancer. So far, little is known about the surveillance pathway that monitors mitochondrial function and activates repair programs upon mitochondrial stress. I will describe a genome-wide RNAi screen in C. elegans which identified factors that oversee mitochondrial function. It has revealed the critical roles of ceramide signaling and the mevalonate pathway in mitochondrial surveillance. Genes identified from the genetic screen hold great promise for in-depth studies of mitochondrial surveillance, which could provide novel perspectives on the therapeutics of mitochondrial disorders and age-related diseases such as neurodegeneration.
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