学术报告
题目：Molecular Mechanisms Underlying Self-renewal and Migration of Normal and Tumor-initiating Stem Cells
报告人：Yan Song, Ph.D
Dept. of Pathology, School of Medicine, Stanford University
时间：Thursday 2:00 p.m, May 31
地点：生命科学学院411会议室
Stem cells yield promise for regenerative medicine but also pose huge challenges. It remains uncertain how to inhibit stem-cell-derived tumor formation without harming normal stem cells. It is likewise unclear how directional stem cell migration, a critical step in tissue regeneration, is orchestrated. I have utilized newly-established/previously-unexplored stem cell models to understand the fundamental principles governing self-renewal and migration of normal and cancer stem cells (CSCs). Using neural stem cells in the Drosophila brain as a simple yet powerful model to recapitulate CSC-initiated brain tumor, I found that reduction in cell growth, which is mediated by a Notch signaling cascade and a Myc-eIF4E regulatory loop, represents an effective strategy for selective elimination of CSCs. In addition, I have identified and established Drosophila kidney stem cells as a novel, in vivo model for studying directional stem cell migration. My work revealed how guidance cues may be converted into physical movement of stem cells in development and upon tissue injury. Combining genetic and biochemical approaches as well as in vivo imaging, these studies promise to unravel new strategies for tissue regeneration and anticancer therapy.
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