2012年春季遗传发育进展学术讲座
题目1：Essential signaling networks during vascular morphogenesis
报告人：M. Luisa Iruela-Arispe教授
题目2：Wnt signals are required for maintenance of adult mesenchymal stem cell
报告人：Timothy F. Lane教授
时间：5月17日（星期四），下午2: 00－4: 30
地点：新生物楼311会议室
联系人：张博（59072）
1. M. Luisa Iruela-Arispe教授
Major Research Interests:
• Regulation of Angiogenesis during Development and in Disease • Effect of Steroid Hormones on Endothelial Cells • Extracellular Matrix Proteins and Modulation of Angiogenesis Representative publications:
(1) Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML. 2010. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 18(1):39-51.
(2) Zovein, A.C., Hofmann, J.J., Lynch, M., French, W.J., Turlo, K.A., Yang, Y., Becher, M.S., Zanetta, L., Dejana, E., Gasson, J., Tallquist, M.D., and Iruela-Arispe, M.L. 2008. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell 3(6):625-636. (Cover)
(3) Lee, S., Chen, T.T., Barber, C.L., Jordan, M.C., Murdock, J., Desai, S., Ferrara, N., Nagy, A., Roos, K.P., Iruela-Arispe, M.L. 2007. Autocrine VEGF signaling is required for vascular homesostasis. Cell, 130:691-703.
(4) Lee, N.V., Sato, M., Annis, D.S., Loo, J.A., Wu, L., Mosher, D.F. and Iruela-Arispe, M.L. 2006. ADAMTS1 mediates the release of anti-angiogenic polypeptides from TSP1 and TSP2. EMBO J. 25:5270-5283.
(5) Lee, S., Jilani, S.M. Nikolova, G.V., Carpizo, D., and Iruela-Arispe, M.L. 2005. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J. Cell Biol. 169(4):681-691. (Cover)
2. Timothy F. Lane教授
Major Research Interests:
• Genetic regulation of Cancer Progression • Origin of tumor microvascular cells and role of circulating endothelial precursors in the progression of breast and ovarian cancer • Role of wnt genes in maintenance of stem cell microenvironments in breast and bone • Role of genetic differences underlying Health Disparities Representative publications:
(1) Stevens JR, GA Miranda, MA Singer, SM Brugger, K Lyons, TF Lane (2010). Wnt10b deficiency results in age dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. Journal of Bone and Mineral Research. 25(10):2138-47.
(2) Miranda GA, SA Krum, Q Deng, A Collado Hidalgo, K Yee, M Nava, M Singer, Z Galic, JA Zack, K Nakayama, KI Nakayama, TF Lane (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes and Development 22:3121-34
(3) Chadwick BP, TF Lane (2005) BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation. Chromosoma 114:432-9
(4) Krum SA, GA Miranda, C Lin, TF Lane (2003). BRCA1 associates with hyper-phosphorylated RNA polymerase II. Journal of Biological Chemistry. 278:52012-52020.
(5) Krum SA, JE Womack, TF Lane (2003). Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. Oncogene. 22: 6032-6044.
欢迎各位老师和同学们积极参加！