学术报告
题目：Tripartite regulation of a single locus neurotrophins GDNF, DNSP and GDNFOS in human brain diseases
报告人：Tim Qing-Rong Liu, Ph.D.
Staff Scientist, Behavior Neurobiology Research Branch,
National Institute on Drug Abuse, National Institute of Health, USA
时间：2011年12月2日（周五）下午3-4 PM
地点：生命学院610室
Abstract:
Background: Glial cell line-derived neurotrophic factor (GDNF) has been effective therapy in laboratory animal models of Parkinson`s disease.
Results: A human de novo gene, GDNFOS (GDNF Opposite Strand), was discovered and encodes a 105 amino acid secreted peptide. A dopamine neuron stimulating peptide (DNSP) was found in the proregion of GDNF alpha isoform transcribed from a human-specific promoter.
Conclusion: GDNF, DNSP and GDNFOS are differentially regulated in middel temporal gyrus of Alzheimer`s disease.
Significance: GDNF, DNSP and GDNFOS neurotrophins may be used in treatment of human neurodegenerative diseases.
Recent original Research Articles
1. Airavaara M., Pletnikova O., Doyle M.E., Zhang Y.E., Troncoso J.C., and Liu Q.-R. (2011) Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer`s disease. J. Biol. Chem. [Epub ahead of print].
2. Xi Z.-X., Peng X.-Q., Li X., Song R., Zhang H., Liu Q.-R., Yang H.-J., Bi G.-H., Li JH., Gardner E.L. (2011) Brain cannabinoid
CB2 receptors modulate cocaine`s actions in mice. Nat. Neurosci. [Epub ahead of print].
3. Kobilo T., Liu, Q.-R., Gandhi K., Mughal M., Shaham Y., and van Praag H. (2011) Running is the neurogenic and neurotrophic stimulusin environmental enrichment. Learn. Mem. 18, 605-609
4. Li C.Y., Zhang Y., Zhang P.W., Lu S.J., Li X.M., Yu Q., Zheng X., Du Q, Uhl G.R., Liu, Q.-R., and Wei L. (2010) A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions. PloS Computation Biology 6, e 1000734.
5. Liu Q.-R., Pan CH, Hishimoto A, Li CY, Xi ZX, Llorente-Berzal A, Viveros MP, Ishiguro H, Arinami T, Onaivi ES, Uhl GR. (2009) Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes Brain Behav. 8, 519-530.
6. Han, J.C., Liu, Q.-R., Jones, M.P., Levinn, R.L., Menzie, C. M., BS, Kyra S. Jefferson-George, K.S., Adler-Wailes, D. C., Sanford, E.
L., Lacbawan, F.L., Uhl, G.R., Rennert, O.M., and Yanovski, J.A.
(2008) Brain-Derived Neurotrophic Factor in Human Energy Balance: WAGR Syndrome as a Model for BDNF Haploinsufficiency. New Engl. J. Med.
359, 918-927.
7. Hishimoto, A., Liu, Q.-R., Drgon, T., Pletnikova, O., Walther, D., Zhu, X.-G. Troncoso, J.C., and Uhl, G.R. (2007) Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. Hum. Mol. Genet. 16, 2880-2891.
8. Liu, Q.-R., Drgon, T., Walther, D., Johnson, C., Poleskaya, O., Hess, J., and Uhl, G.R. (2005) Pooled association genome scanning:
validation and use to identify addiction vulnerability loci in two samples. Proc. Natl. Acac. Sci. U. S. A. 102, 11864-11869.
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