题目：Molecular Basis of Cancer Metastasis
报告人：Yibin Kang,
Warner-Lambert/Parke-Davis Professor,
Department of Molecular Biology, Princeton University.
时间：2013年6月3日（周一），上午10：00-11：30 AM
地点：生命科学学院一楼邓祐才报告厅
联系人：范琳琳（电话：15210608645）
Abstract:
Metastasis represents the most devastating stage of cancer progression and is responsible for most of cancer-related death. We apply a multidisciplinary approach to analyze the molecular basis of breast cancer metastasis and revealed the role of novel metastasis genes in mediating cell-intrinsic changes and tumor-stromal interactions essential for different steps of metastatic progression. We showed that loss of Elf5, an important gene in alveolar luminal cell fate determination, mediate epithelial-mesenchymal transition and tumor invasion. We further discovered a TGFβ-Notch network of tumor-stromal interactions in osteolytic bone metastasis. These findings suggest novel avenues for therapeutic treatment of metastatic breast cancer.
Selected publications:
1. Sethi N, Dai X, Winter CG, and Kang Y. (2011) Tumor-derived Jagged1 promotes osteolytic bone metastasis of breast cancer by activating stromal Notch signaling. Cancer Cell, 19:192-205. (Cover Article) PMID: 21295524
2. Korpal M, Ell BJ, Buffa FM, Ibrahim T, Terrasa AC, Mercatali L, Khan Z, Blanco MA, Goodarzi H, Hua Y, Wei Y, Hu G, Garcia B, Ragoussis J, Amadori D, Harris AL, and Kang Y. (2011) Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nature Medicine, 17:1101–1108. (Cover Article) PMID: 21822286
3. Sethi N and Kang Y. (2011) Unraveling the complexity and dynamics of metastasis: from molecular understanding to targeted therapeutics. Nature Reviews Cancer, 11(10):735-748. PMID: 21941285
4. Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, Yan J, Hua Y, Tiede BJ, Lu X, Reiss M, Haffty BG, Pantel K, Massagué J, and Kang Y. (2011) VCAM1 promotes osteolytic expansion of indolent bone micrometastases of breast cancer by engaging a4b1-positive osteoclast progenitors. Cancer Cell 20:701-14. (Featured Article) PMID: 22137794.
5. Chakrabarti R, Hwang J, Blanco MA, Wei Y, Lukacisin M, Romano R, Smalley K, Liu S, Yang Q, Ibrahim T, Mercatali L, Amadori D, Haffty BG, Sinha S and Kang Y (2012) Elf5 inhibits epithelial mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2/Slug. Nature Cell Bio., 14(11):1212-22. (Cover Article). PMID: 23086238.
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