Abstract

Recent approaches to the study of developmental genetic mechanisms involved in initiation and patterning of paired appendages among different taxa have provided clues to understanding the evolutionary origin of vertebrate limbs. Numerous genetic approaches using chick and mouse embryos have revealed the novel function and control of key regulators of limb development. In addition to these genetic approaches, comparative expression analyses on non-model vertebrates occupying critical phylogenetic positions have shed light on the organization of the vertebrate body plan in relation to the development of paired appendages. In this seminar, I introduce recent progress of our research on these areas and also provide an integrated account of the broad impact of developmental approaches to address the evolution from fins into limbs.

 

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