Wells教授是protein engineering、drug discovery, protease signaling pathway 等领域的权威专家。参见页面 http://wellslab.ucsf.edu/index.htm

Abstract

Apoptosis, or programmed cell death, represents an ultimate fate decision in cell biology. This process is critical for cellular differentiation and remodeling of tissues, and for anti-viral and anti-tumor defense. A distinct molecular feature of apoptosis is the widespread but controlled cellular proteolysis, that is predominantly mediated by eight members of the caspase family of cysteine proteases. These enzymes are like demolition experts that cleave protein targets critical for cellular life. I’ll be presenting newly designed enzymes and small molecules to study and activate individual caspases and the proteins they cleave.

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