学术报告
题目：Signaling Crosstalk Regulates Glucose Homeostasis
报告人：Yiguo Wang, Ph.D.
Salk Institute for Biological Studie
时间： Thursday 10:00 a.m., April 26
地点：生命科学学院517会议室
Hyperglycemia is one of the major hallmarks of Type 2 diabetes, which is epidemic in the world. It is very important to understand the signaling mechanisms that regulate glucose homeostasis. In the fasted state, circulating pancreatic glucagon stimulates hepatic glucose production in part through the CREB regulated transcription coactivator 2 (CRTC2). In addition, it is well known that endoplasmic reticulum (ER) stress is increased in obesity and diabetes. However, whether ER stress directly modulates glucose production and how fasting signaling promotes CRTC2-dependent glucose production are unclear. Here, we show that CRTC2 links ER stress signaling and hepatic glucose production. Also, we show how signaling crosstalk between calcium signaling and fasting signaling induces CRTC2-dependent elevation of blood sugar. Taken together, our results demonstrate how signaling crosstalks among calcium signaling, ER stress signaling and fasting-induced cAMP signaling contribute to glucose homeostasis.
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