学术报告
题目：DNA damage response and cancer
报告人：Aimin Peng, Ph.D.
Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center
时间：Wednesday 9:30 a.m., February 15
地点：生命科学学院411会议室
The DNA damage response (DDR) is a critical tumor suppression mechanism and an important determinant in cancer therapy. Although extensive efforts were put into revealing the activation network of the DDR, little is known about how it is turned off in cancer cells to allow cancer progression and tumor recurrence after chemotherapy. We use comprehensive approaches to delineate new mechanisms of DDR regulation, and to investigate their implications for cancer etiology and therapy. Our recent studies in protein phosphatase-dependent regulation of the DDR and the involvement of Greatwall kinase in DDR recovery and tumor recurrence will be discussed.
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