学术报告
题目：Evolution of transcriptional regulation -- view from both “Cis” and “Trans”
报告人：Bin He, Ph.D.
Postdoctoral fellow of Erin O’Shea’s Lab
Howard Hughes Medical Institute, Center for Systems Biology,
Harvard University
时间：2013年12月17日（周二），14:00-15:00 PM
地点：生命科学学院311会议室
In this talk I will touch on two aspects in regulatory evolution (transcriptional): “cis” refer to the DNA binding sites in gene regulatory regions, while “trans” means the transcription factor proteins and the networks they form. In the first part, I will use results from Drosophila data to argue that the observed fast turnover (evolutionary gain and loss) of transcription factor binding sites are not due to a strictly neutral process; to the contrary, natural selection, in particular positive selection has played an important role in shaping the evolutionary dynamics in transcriptional enhancer regions. In the second part, I will switch to the trans-regulators to discuss the evolution of cooperativity between transcription factors. To illustrate the importance and evolutionary dynamics of this prevalent feature in eukaryote transcriptional regulation, I took advantage of an evolved difference between two yeast species, which differ in how they regulate phosphate starvation response. In particular, one species, the model organism Saccharomyces cevervisiae, requires two transcription factors working in coordination, while the other species, Candida glabrata, seems to have largely forgone this requirement, by allowing one transcription factor to take over the function. I will discuss the functional impact of this shift on the downstream genes, as well as its evolutionary impact in the context of the two species native environment. In summary, I hope to use the two examples from both cis and trans perspectives to gain insight into general principles in regulatory evolution.
联系人：李晴（电话：62752516）
欢迎各位老师和同学积极参加！