学术报告
题目：Metabolic Control by p53 Family Members in Cancer
报告人：Peng Jiang, Ph.D
Perelman School of Medicine, University of Pennsylvania,
时间：2013年11月21日（周四）上午 10:00 AM
地点：生命学院311室
One of the major biochemical hallmarks of cancer cells is a metabolism switch whereby cancer cells consume more glucose and glutamine than normal tissue, and favor a less efficient but rapid metabolic mechanism for energy production. Abnormal metabolic reprogramming and oncogene/tumor suppressor mutations are primary causes for many human cancer diseases. Of note, the metabolic rewiring of cancer cells can be linked to specific genetic alterations in oncogenes and tumor suppressor genes responsible for cell signaling. However, it still remains a mystery how this might happen and how exactly metabolism is altered by signal transduction changes in cancer cells and what advantages these alterations afford. Here, I will discuss the new role of tumor suppressor p53 in metabolic regulation and a role of p53 as a metabolic sensor that integrate metabolic stresses with cell fate decisions, including cellular aging or senescence. Additionally, I will also discuss the importance of the pentose phosphate pathway (PPP) in tumor growthand how PPP flux is altered by a p53related protein p73, whose role in tumor cells had remained an enigma for many years.
欢迎各位老师和同学积极参加！