学术报告
题目：Mapping brain plasticity with fMRI to drive mechanistic discoveries in the rodent brain
报告人：Xin Yu. PhD
National Institute of Neurological Disorders and Stroke, National Institutes of Health, USA
时间： Thursday 10:30 a.m., September 13th
地点：生命科学学院金光大楼516会议室
FMRI can map brain functional changes in the system level. Slice electrophysiology, such as patch clamp, is used to analyze the cellular mechanisms of synaptic plasticity. How to use fMRI results to steer system-to-synaptic plasticity studies remains challenging. We first developed a navigation strategy to use the data acquired by fMRI and manganese-enhanced MRI to guide slice electrophysiology. Here, we reported novel post-critical period thalamocortical plasticity in the adolescent rat brain following peripheral nerve injury. The global feature of fMRI also leads us to identify the interhemispheric plasticity detected in the deafferented cortex. Preliminary study has been performed to implement optogenetic tools in fMRI to map the callosal fiber mediated brain function across the two hemispheres. Future study will be focused on using optogenetic tools to manipulate callosal activity in either adaptive or maladaptive interhemipheric plasticity to facilitate the functional recovery in animal models with stroke, epilepsy, or peripheral nerve injuries.
欢迎各位老师和同学积极参加！