学术报告
题目：Vascular Niche Regulation of Organ Regeneration
报告人： Bi-Sen Ding, Ph.D.
Weill Cornell Medical College & Howard Hughes Medical Institute
时间：Thursday 1:00 p.m., May 24
地点：生命科学学院517会议室
The primary goal of my research is to understand regulation of organ regeneration by environmental cues from non-parenchymal cells (niche). Utilizing mouse genetic models of liver and lung regeneration, I aim to answer fundamental questions related to regeneration: 1) how do organs balance between regeneration, mal-adaptive fibrosis, and tumorigenesis? 2) how does “position memory” dictate the original functional and anatomical structures during regeneration? 3) how is programmed regeneration switched on upon injury and terminated after reaching certain “set-points”?
My previous studies have demonstrated that during regeneration, blood vessel not only serve as passive conduit for oxygen delivery, but also elaborate instructive cues (vascular niche) to orchestrate the programmed tissue renewal of liver and lung, while avoiding fibrosis and tumorigenesis.
This vascular niche-initiated organ regeneration resembles the inductive role of endothelial cells (ECs) in developmental neurogenesis and organogenesis of pancreas and liver. Elucidating how this "perfusion-independent" vascular niche orchestration of regeneration is initiated, balanced, and terminated, will shed mechanistic light on 3 fundamental questions raised above.
欢迎各位老师和同学积极参加！