Protein
expression and modifications play key roles in regulating the cell’s function
and human disease state. We mainly focuses on the protein expression changes in
brain aging, neurodegenerative diseases, cancer cell surface protein targets
and biomarkers by quantitative proteomics. Ongoing projects include protein quantification,
acetylation and phosphorylation characterization in AD and PD, high throughput
profiling of CRC cancer cell surface specific
protein targets and development of the new antibody-drug conjugates.
