Frock RL#, Hu J#, & Alt FW. (2015). Mechanisms of recurrent chromosomal translocations. In book: Chromosomal Translocations and Genome Rearrangements in Cancer. Springer International Publishing, ISBN: 978-3-319-19983-2. doi: 10.1007/978-3-319-19983-2
代表性论文 (# 共同一作, *共同通讯)
Liu Y#, Zhangding Z#, Liu X#, Gan T, Ai C, Wu J, Liang H, Chen M, Guo Y, Lu R, Jiang Y, Ji X, Gao N, Kong DC, Li Q & Hu J (2024). Fork coupling directs DNA replication elongation and termination. Science. 2024.Mar; 383(6688):1215-22. doi:10.1126/science.adj7606.
Wu J#, Liu Y#, Zhangding Z#, Liu X#, Ai C, Gan T, Liang H, Guo Y, Chen M, Liu Y, Yin J, Zhang W & Hu J (2023). Cohesin maintains replication timing to suppress DNA damage on cancer genes. Nature Genetics. 2023.Aug; 55(8):1347-1358. doi:10.1038/s41588-023-01458-z.
Yin J#, Fang K#, Gao Y#, Ou L, Yuan S, Xin C, Wu W, Wu W-W, Hong J, Yang H*, & Hu J* (2022) Safeguarding genome integrity during gene-editing therapy of age-related macular degeneration. Nature Communications 13(1):7867. doi: 10.1038/s41467-022-35640-4.
Yin S#, Zhang M#, Liu Y#, Sun X, Chen X, Yang L, Huo Y, Yang J, Zhang X, Han H, Zhang J, Li G, Xiao M, Guan Y, Liu M, Hu J*, Wang L* & Li D* (2022) Engineering of efficiency enhanced Cas9 and base editors with improved gene therapy efficacies. Molecular Therapy S1525-0016(22)00672-4. doi: 10.1016/j.ymthe.2022.11.014.
Wu J#, Zou Ziye#, Liu Y#,*, Liu X, Zhangding Z, Xu M* & Hu J* (2022). CRISPR/Cas9-induced structural variations expand in T lymphocytes in vivo. Nucleic Acids Research 50(19):11128-11137. doi: 10.1093/nar/gkac887.
Xin C#, Yin J#, Yuan S, Ou L, Liu M, Zhang W & Hu J (2022). Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption. Nature Communications 13(1):5623. doi: 10.1038/ s41467-022-33346-1.
Chen X#, Niu X#, Liu Y#, Zheng R, Yang L, Lu J, Yin S, Wei Y, Pan J, Sayed A, Ma X, Liu M, Jing F, Liu M, Hu J*, Wang L* & Li D* (2022). Long-term correction of haemophilia B through CRISPR/Cas9 induced homology-independent targeted integration. J Genet Genomics S1673-8527(22)00159-X. doi: 10.1016/j.jgg.2022.06.001.
Yin J & Hu J (2022). The origin of unwanted editing byproducts in gene editing. Acta Biochim Biophys Sin 54(6):1-15. doi: 10.3724/abbs.2022056.
Xie X#, Gan T#, Rao B#, Zhang W, Panchakshari RA, Yang D, Ji X, Cao Y, Alt FW, Meng F-L* & Hu J* (2022). C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency. EMBO J 41(11):e109324. doi: 10.15252/embj.2021109324.
Yin J#, Lu R#, Xin C#, Wang Y, Ling X, Li D, Zhang W, Liu M, Xie W, Kong L, Si W, Wei P, Xiao B, LEE HY, Liu T & Hu J (2022). Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing. Nature Communications 8;13(1):1204. doi: 10.1038/s41467-022-28900-w.
Liu Y#,*, Yin J#, Gan T#, Liu M, Xin C, Zhang W & Hu J* (2022). PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair. STAR Protocols 3(1), 101088. doi: 10.1016/j.xpro.2021.101088
Gan T, Wang Y, Schatz DG & Hu J (2021). RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination. Cell Reports 37, 209824. doi:10.1016/j.celrep.2021.109824
Liu M#, Zhang W#, Xin C#, Yin J, Shang Y, Ai C, Li J, Meng F-L & Hu J (2021). Global detection of DNA repair outcomes induced by CRISPR-Cas9. Nucleic Acids Research 49(15):8732-8742. doi: 10.1093/nar/gkab686.
Zhang W#, Yin J#,*, Zhang-Ding Z, Xin C, Liu M, Wang Y, Ai C & Hu J (2021). In-depth assessment of the PAM compatibility and editing activities of Cas9 variants. Nucleic Acids Research doi: 10.1093/nar/gkab507.
Liu Y#, Ai C#, Gan T#, Wu J, Jiang Y, Liu X, Lu R, Gao N, Li Q, Ji X, Hu J (2021). Transcription shapes DNA replication initiation to preserve genome integrity. Genome Biology 22(1):176. doi: 10.1186/s13059-021-02390-3
Yin J#, Liu M#, Liu Y#, Wu J, Gan T, Zhang W, Li Y, Zhou Y & Hu J (2019). Optimizing genome editing strategy by primer-extension-mediated sequencing. Cell Discovery 5, 819. doi: 10.1038/s41421-019-0088-8.
Zuo E#, Huo X#, Yao X#, Hu X#, Sun Y#, Yin J#, He B, Wang X, Shi L, Ping J, Wei Y, Ying W, Wei W, Liu W, Tang C, Li Y, Hu J* & Yang H*. (2017). CRISPR/Cas9-mediated targeted chromosome elimination. Genome Biology 18(1):224. doi: 10.1186/s13059-017-1354-4.
Lin SG#, Ba Z#, Du Z#, Zhang Y, Hu J* & Alt FW*. (2016). A highly sensitive and unbiased approach for elucidating antibody repertoires. Proc Natl Acad Sci USA 113(28):7846-51. doi:10.1073/ pnas.1608649113.
Hu J#, Meyers RM#, Dong J, Panchakshari RA, Alt FW* & Frock RL*. (2016). Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nature Protocols 11(5): 853-71. doi: 10.1038/nprot.2016.043.
Hu J#, Zhang Y#, Zhao L, Frock RL, Du Z, Meyers RM, Meng F-L, Schatz DG, & Alt FW. (2015). Chromosomal loop domains direct the recombination of antigen receptor genes. Cell 163(4): 947-59. doi: 10.1016/j.cell.2015.10.016.
Frock RL#, Hu J#, & Alt FW. (2015). Mechanisms of recurrent chromosomal translocations. In book: Chromosomal Translocations and Genome Rearrangements in Cancer. Springer International Publishing, ISBN: 978-3-319-19983-2. doi: 10.1007/978-3-319-19983-2
Frock RL#, Hu J#, Meyers RM, Ho Y-J, Kii E, & Alt FW. (2015). Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nature Biotechnology 33(2):179-86. doi: 10.1038/ nbt.3101.
Hu J#, Tepsuporn S#, Meyers RM, Gostissa M*, & Alt FW*. (2014). Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proc Natl Acad Sci USA 111(28): 10269-74. doi: 10.1073/pnas.1410112111.
Tepsuporn S#, Hu J#, Gostissa M*, & Alt FW*. (2014). Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immunol. Res. 2(9): 857-66. doi: 10.1158/2326-6066. CIR-14-0090.
Hu J, Sun L, Shen F, Chen Y, Hua Y, Liu Y, Zhang M, Hu Y, Wang Q, Xu W, Sun F, Ji J, Murray JM, Carr AM, & Kong D. (2012). The intra-S phase checkpoint pathway targets Dna2 to prevent stalled replication forks from reversing. Cell 149(6): 1221-32. doi: 10.1016/j.cell.2012.04.030.