教育经历:

2002 – 2006 本科，北京大学生命科学学院，获理学学士学位
2006 – 2011 硕博连读研究生, 北京大学生命科学学院，获理学博士学位

工作经历:

2011 – 2013 博士后，美国克利夫兰医学中心Lerner研究所，细胞与分子医学系
2013 – 2019 博士后，北京大学生命科学学院
2019 至今 副研究员，北京大学生命科学学院

荣誉奖励:

北京大学教学优秀奖，2024
北京大学第二十三届青年教师教学基本功比赛（理工科类）一等奖，2024
北京大学生命科学学院东宝奖教金，2024

杂志任职:

2023 至今 《Journal of Genetics and Genomics》青年编委

执教课程:

本科生 遗传学讨论 春季学期
本科生 发育生物学 春季学期
本科生 发育生物学实验 春季学期

研究生CLS项目 发育生物学基础 秋季学期

      信号转导是发育的基础，贯串生命进程始终。在个体发育中，细胞感知并解析外界和内源发育信号，通过信号转导将其转化为对核内基因的表达调控，从而改变细胞理化状态，协同周围细胞完成发育中的关键细胞学进程。这些发育信号，既包括经典的形态发生素等，也有短肽/氨基酸、糖、脂等代谢产物。信号转导异常精密和准确，信号的产生、识别和解读过程中任何细节的微小误差或失衡都可能会造成发育异常或代谢紊乱。我们围绕“发育信号的调控机制”这一前沿科学问题，以果蝇和小鼠为研究模型，结合果蝇与哺乳动物细胞培养体系，综合经典遗传筛选分析方法、细胞生化手段和先进成像技术，从多角度和多层次探讨发育信号的调控机理，为发育和脂代谢相关疾病的治疗提供理论基础。

Gao Y.*, Feng J.*, Zhang Y., Yi M., Zhang L., Yan Y., Zhu A.J.# and Liu M.# (2024) Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes. EMBO Rep. 25(12): doi: 10.1038/s44319-024-00289-1.

Wang Y., Zhou J., Yang Q., Li X., Oiu Y., Zhang Y.#, Liu M.# and Zhu A.J.# (2024) Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models. J.Lipid Res. 65: 100635.

He T.*, Fan Y.*, Du J., Yi M., Li Y., Liu M.#, Zhu A.J.# (2023) Stuxnet fine-tunes Notch dose during development using a functional Polycomb response element. Development 150: dev201297.

Zhao W.*, Zhang Y.*#, Lin S., Li Y., Zhu A.J., Shi H.#, Liu M.# (2023) Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle. J. Cachexia Sarcopenia Muscle 14: 1454-1467.

Zhang Y.*, Lin S.*, Peng J.*, Liang X., Yang Q., Bai X., Li Y., Li J., Dong W., Wang Y., Huang Y., Pei Y., Guo J., Zhao W., Zhang Z., Liu M.#, Zhu A.J.# (2022) Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination. Mol. Cell 82: 1528-1542.

He T.*, Fan Y.*, Wang Y., Liu M.#, Zhu A.J.# (2022) Dissection of the microRNA network regulating Hedgehog signaling in Drosophila. Front. Cell Dev. Biol. 10: 866491.

Liu M.*, Su Y.*, Peng J., Zhu A.J. (2021) Protein modifications in Hedgehog signaling. BioEssays 43: e2100153.

Gan T.*, Fan L.*, Zhao L., Misra M., Liu M., Zhang M.#, Su Y.# (2021) JNK signaling in Drosophila aging and longevity. Int. J. Mol. Sci. 22: 9649.

Zhang Y.*, Teng D.*, Lu W. *, Liu M.*, Zeng H., Cao L., Southcott L., Potdar S., Westerman E., Zhu A.J.#, Zhang W.# (2021) A widely diverged locus involved in locomotor adaptation in Heliconius butterflies. Sci. Adv. 7: eabh2340.

Liu M.*, Liu A.*, Wang J.*, Zhang Y., Li Y., Su Y.#, Zhu A.J.# (2021) Competition between two phosphatases fine-tunes Hedgehog signaling. J. Cell Biol. 220: e202010078.

Liu M.*, Li Y.*, Liu A., Li R., Su Y., Du J., Li C., Zhu A.J.# (2016) The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development. eLife 5: e17200.

Du J.*, Zhang J.*, He T., Li Y., Su Y., Tie F., Liu M., Harte P.J., Zhu A.J.# (2016) Stuxnet facilitates the degradation of polycomb protein during development. Dev. Cell 37: 507-519.

Zhang J., Du J., Lei C., Liu M., Zhu A.J.# (2014) Ubpy controls the stability of the ESCRT-0 subunit Hrs in development. Development 141: 1473-1479.

Gao G.*, Vibranovski M. D.*, Zhang L., Li Z., Liu M., Zhang Y. E., Li X., Zhang W., Fan Q., VanKuren N. W., Long M.#, Wei L.# (2014) A long-term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster. Genome Res. 24: 629-638.

Zhang J.*, Liu M.*, Su Y., Du J., Zhu A.J.# (2012) A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. G3 (Bethesda) 2: 1563-1575.

Du J., Zhang J., Su Y., Liu M., Ospina J.K., Yang S., Zhu A.J.# (2011) in vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling. PLoS One 6: e24168.

Liu M.*, Liu P.*, Zhang L., Gao G., Zhang W., Zhu Z., Liu D.#, Fan Q.# (2011) mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans. Cell Res. 21: 1605-1618.

Wang X.*, Liu M.*, Li W., Suh CD., Zhu Z., Jin Y., Fan Q.# (2009) The function of a spindle checkpoint gene bub-1 in C. elegans development. PLoS One 4: e5912.

Li Z.*, Liu M.*, Zhang L.*, Zhang W., Gao G., Zhu Z., Wei L., Fan Q.#, Long M.# (2009) Detection of intergenic non-coding RNAs expressed in the main developmental stages in Drosophila melanogaster. Nucleic Acids Res. 37: 4308-4314.

实验室成员：
董 巍、刘 敏、冯婧
博士后：张乐冰、张延松（博雅博士后)、范 昱 (博雅博士后)、林思远 (博雅博士后)
研究生：黄 颖 (SLS)、王 洁 (SLS)、亓 淼 (PTN)、杨 琪 (SLS)、李锦华 (SLS)、王 尧 (SLS)、徐 滢 (SLS)、杨 迪 (SLS)、孟心瀚 (PTN)、苏 桐 (SLS)、李常清 (SLS)、程启翔（PTN)、李逸之 (4+4)
客座学生：李佳义
本科生：蒋馨欧，战阳阳、姚嘉一、邹瀚琳、周佳欣、潘彦哲、顾欣怡、张惠雯
实验室电话(010)-6276-1444