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本实验室致力于研究RNA修饰/non-coding RNA的分子调控机制和相关生物功能。我们运用表观遗传学，分子生物学，结合高通量测序等多种技术手段来探索RNA修饰/ncRNA对于染色质结构和基因转录的新的调控机制，以及相关调控通路在胚胎干细胞分化，抗肿瘤免疫，癌症及衰老中的生物功能。

主要研究方向：

1. 拓展染色质RNA修饰参与调控染色质功能的新型分子调控机制；

2. 解析染色质RNA修饰-染色质互作及在早期胚胎发育，干细胞命运决定，衰老及相关疾病，自身免疫疾病和癌症发展等过程中的相关生物功能；

3. 建立RNA/RNA表观遗传修饰精准功能解析及生物大分子互作相关的研究体系。

^{1. Zihong Kang#, Ruimeng Li#, Chang Liu, Xiaozhe Dong, Yuxuan Hu, Lei Xu, Xinyu Liu, Yunfan Xiang, Liming Gao, Wenzhe Si, Lei Wang, Qing Li, Liang Zhang, Huan Wang, Xuerui Yang*, Jun Liu*, m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells, Cell, 2024, 187(21), 6035-6054.}

^{2. Yini Li#, Xiaoyang Dou#, Jun Liu#, Yu Xiao#, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W Ostrow, Chuan He*, Shuying Sun*, Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration, Nature Neuroscience, 2023, 26(8): 1328-1338.}

^{3. Xiaoyang Dou#, Lulu Huang#, Yu Xiao#, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He*, Jun Liu*, METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity, Protein & Cell, 2023, pwad009.}

^{4. Jun Liu#, Xiaoyang Dou#, Chuanyuan Chen#, Chuan Chen, Chang Liu, Meng Michelle Xu, Siqi Zhao, Bin Shen, Yawei Gao*, Dali Han*, Chuan He*, N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription, Science, 2020, 367(6477): 580-586.}

^{5. Min Wang#; Jun Liu#; Yan Zhao#; Ruizhi He#; Xiaodong Xu#; Xingjun Guo; Xu Li; Simiao Xu; Ji Miao; Jianpin Guo; Hang Zhang; Jun Gong; Feng Zhu; Rui Tian; Chengjian Shi; Feng Peng; Yechen Feng; Shuo Yu; Yu Xie; Jianxin Jiang; Min Li*; Wenyi Wei*; Chuan He*; Renyi Qin*; Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer, Molecular Cancer, 2020, 19(130).}

^{6. Dali Han#*, Jun Liu#, Chuanyuan Chen, Lihui Dong, Yi Liu, Renbao Chang, Xiaona Huang, Yuanyuan Liu, Jianying Wang, Urszula Dougherty, Marc B Bissonnette, Bin Shen, Ralph R Weichselbaum, Meng Michelle Xu*, Chuan He*, Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells, Nature, 2019, 566(7743): 270-274.}

^{7. Jiajie Hou#*; He Zhang#; Jun Liu#; Zhenjun Zhao; Jianye Wang; Zhike Lu; Bian Hu; Jiankui Zhou; Zhicong Zhao; Mingxuan Feng; Haiyan Zhang; Bin Shen; Xingxu Huang; Beicheng Sun; Chuan He*; Qiang Xia*; YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma, Molecular Cancer, 2019, 18(163).}

^{8. Jun Liu#, Mark A Eckert#, Bryan T Harada#, Song-Mei Liu#, Zhike Lu, Kangkang Yu, Samantha M Tienda, Agnieszka Chryplewicz, Allen C Zhu, Ying Yang, Jing-Tao Huang, Shao-Min Chen, Zhi-Gao Xu, Xiao-Hua Leng, Xue-Chen Yu, Jie Cao, Zezhou Zhang, Jianzhao Liu, Ernst Lengyel*, Chuan He*, m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer, Nature Cell Biology, 2018, 20(9): 1074-1083.}

^{9. Jun Liu#; Guanzheng Luo#; Juan Sun; Lili Men; Honggang Ye; Chuan He; Decheng Ren*; METTL14 is essential for β-cell survival and insulin secretion, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019, 1865(9): 2138-2148.}

^{10. Yanan Yue#; Jun Liu#; Xiaolong Cui#; Jie Cao#; Guanzheng Luo; Zezhou Zhang; Tao Cheng; Minsong Gao; Xiao Shu; Honghui Ma; Fengqin Wang; Xinxia Wang; Bin Shen; Yizhen Wang; Xinhua Feng; Chuan He*; Jianzhao Liu*; VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation, Cell Discovery, 2018, 4(10).}

^{11. Jun Liu#; Bryan T Harada#; Chuan He; Regulation of gene expression by N6-methyladenosine in cancer, Trends in Cell Biology, 2019, 29(6): 487-499.}

^{(#co-authors contributed equally; *Corresponding authors)}