Committee

Shiqiang Wang

E-mail : wsq@pku.edu.cn

Job title :
Professor

Office Address : Jinguang Life Science Building, Peking University, No.5 Yiheyuan Road, Haidian District, Beijing, P.R.China 100871

EDUCATION EXPERIENCE

1999.1 - 2003.11, Postdoctoral fellow and Research Associate, National Institute on Aging, NIH
1992.9 - 1998.7, Ph.D., Physiology, Peking University
1986.9 - 1990.7, B.S., Physiology & Biophysics, Peking University

WORK EXPERIENCE

2003.8 - present, Professor, College of Life Sciences, Peking University
1999.7 - 2003.7, Associate Professor, College of Life Sciences, Peking University
1994.7 - 1999.6, Lecturer, College of Life Sciences, Peking University
1990.8 - 1994.6, Assistant Lecturer, Department of Biology, Peking University

RESEARCH DESCRIPTION

2003.8 - present, Professor, College of Life Sciences, Peking University
1999.7 - 2003.7, Associate Professor, College of Life Sciences, Peking University
1994.7 - 1999.6, Lecturer, College of Life Sciences, Peking University
1990.8 - 1994.6, Assistant Lecturer, Department of Biology, Peking University

SELECTED PUBLICATIONS

1. Zhao YT, Guo YB, Gu L, Fan XX, Yang HQ, Chen Z, Zhou P, Yuan Q, Ji G, Wang SQ (2017) Sensitized signaling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. Cardiovascular Research, 113(3):332-342.
2. Cheng HY, Wang SQ, Feng RQ (2016) STIM1 plays an important role in TGF-β-induced suppression of breast cancer cell proliferation. Oncotarget 7(13):16866-16878.
3. Xiao E, Yang H, Gan YH, Duan DH, He LH, Guo Y, Wang SQ*, Zhang Y* (2015) TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells. Stem Cells, 33(2):615-21
4. Shang W, Lu F, Sun T, Xu J, Li LL, Wang Y, Wang G, Chen L, Wang X, Cannell MB, Wang SQ*, Cheng H* , Imaging Ca2+ Nanosparks in Heart with a New Targeted Biosensor , Circulation Research , 2014 , doi: 10.1161/CIRCRESAHA.114.302938
5. Li RC, Tao J, Guo YB, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M, Wang SQ*. , In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice. , Circulation Research, , 2013 , 112: 601-605　
6. Zhang HB, Li RC, Xu M, Xu SM, Lai YS, Wu HD, Xie XJ, Gao W, Ye H, Zhang YY, Meng X, Wang SQ* , Ultrastructural Uncoupling between T-tubules and Sarcoplasmic Reticulum in Human Heart Failure. , Cardiovasc. Res. , 2013 , 98, 269-276.　　
7. Xu M, Wu HD, Li RC, Zhang HB, Wang M, Tao J, Feng XH, Guo YB, Li SF, Lai ST, Zhou P, Li LL, Yang HQ, Luo GZ, Bai Y, Xi JZ J., Gao W, Han QD, Zhang YY, Wang XJ*, Meng X, and Wang SQ* , MiR-24 regulates junctophilin-2 expression in cardiomyocytes , Circulation Research , 2012 , 111: 837-841 　　
8. Wu HD, Xu M, Li RC, Guo L, Lai YS, Xu SM, Li ll, Lü QL, Zhang HB, Zhang YY, Zhang CM and Wang SQ* , Ultrastructural Remodeling of Ca2+ Signaling Apparatus in Failing Heart Cells , Cardiovascular Research , 2012 , 95: 430-438 　　
9. Li XC, Wei L, Zhang GQ, Bai ZL, Hu YY, Zhou Z, Bai SH, Chai Z, Lakatta EG, Hao XM, Wang SQ* , Ca2+ cycling in heart cells from ground squirrels: adaptive strategies for intracellular Ca2+ homeostasis. , PLoS One 6 , 2011 , e24787.　　
10. Guo YB, Wen Y, Gao WX, Li JC, Zhou P, Bai ZL, Zhang B and Wang SQ* , The formation of Ca2+ gradients at the cleavage furrows during cytokinesis of Zebrafish embryos. , Front. Biol. , 2010 , 5, 369-377.　　
11. Zhou P, Zhao YT, Guo YB, Xu SM, Bai SH, Lakatta EG, Cheng H, Hao XM, Wang SQ* , Beta-Adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel , Proc. Natl. Acad. Sci. U. S. A. , 2009 , 106: 18028-18033
12. Tang AH, Wang SQ* , Transition of spiral calcium waves between multiple stable patterns can be triggered by a single calcium spark in a fire-diffuse-fire model , Chaos , 2009 , 19(3)No. 037114　
13. Xu M, Zhou P, Xu SM, Liu Y, Feng XH, Bai SH, Bai Y, Hao XM, Han QD, Zhang YY*, Wang SQ* , intermolecular Failure of L-type Ca2+ Channel and Ryanodine Receptor Signaling in Hypertrophy. , PLoS Biol. , 2007 , 5: e21,0203-0211.
14. Zhou C, Tai C, Ye HH, Ren X, Chen JG, Wang, SQ*, Chai Z* , Interleukin-1b downregulates the L-Type Ca channel activity by depressing the expression of channel protein in cortical neurons. , J. Cell. Physiol. , 2006 , 206, 799-806.
15. Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ* , Temperature dependence and thermodynamic properties of Ca sparks in rat cardiomyocytes. , Biophys. J. , 2005 , 89, 2533-2541.　　
16. Wang SQ, Stern MD, Ríos E, Cheng H , The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array , Proc. Natl. Acad. Sci. U. S. A. , 2004 , 101: 3979-3984　
17. Wang SQ, Wei CL, Zhao GL, Brochet DXP, et al , Imaging microdomain Ca2+ in muscle cells , Circ. Res. , 2004 , 94: 1011-1022. Review　　
18. Liao XD, Tang AH, Chen Q, Jin HJ, Wu CH, Chen LY, Wang SQ* , Role of Ca2+ signaling in initiation of stretch-induced apoptosis in neonatal heart cells. , Biochem Biophys Res Commun. , 2003 , 310, 405-411.　　
19. Wang SQ, Song LS, Xu L, Meissner G, Lakatta EG, Rios E, Stern MD, Cheng H* , Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca2+ sparks. , Biophys. J. , 2002 , 83, 242-251.　　
20. Wang SQ ,Song LS, Lakatta EG, Cheng H , Ca2+ signaling between single L-type Ca2+ channels and ryanodine receptors in heart cells , Nature , 2001 , 410: 592-596.

LABORATORY INTRODUCTION

Molecular mechanism of calcium signaling