[Journal Club] Alcohol: Dangerous or not?Jun.09.2018
Speaker：Jingliang Zhang (张景亮) Yiming Yan (燕逸铭) Changfeng Chen (陈长风) Wentao Dong (董文涛) Yuyang Chen (陈雨旸)
All kinds of alcohol drink can be surly attractive for many people. But recently there is report saying that the consumption of alcohol contributes to global mortality and cancer development. As we all know, most of the toxic effects of alcohol are probably caused by its oxidation product acetaldehyde, which is highly reactive towards DNA. In humans, deficiency in DNA-crosslink repair causes the inherited illness Fanconi anaemia, a devastating condition that leads to abnormal development, bone-marrow failure and cancer. Those reports suggest us to keep away from alcohol. However, resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. And its identification as a chemopreventive agent for skin cancer and reports that it activates sirtuin deacetylases also confirm that drinking some wine maybe not so bad.
1. Dr. Qing Li (PKU)
2. Dr. Jianyuan Luo (PKU)
3. Dr. Yajun Xu (PKU)
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1. Lagouge M, Argmann C, Gerharthines Z, et al. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell, 127(6):1109-1122.
2. Garaycoechea J I, Crossan G P, Langevin F, et al. (2018) Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature, 553(7687):171.