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Journal Club | Intratumor Heterogeneity and Cancer Evolution

May.19.2019

Speaker:Siya Xie(谢思雅)Yuxiang Huang(黄宇翔)Wenbin Mei(梅文彬)Wei Lu(卢巍)

Time:10:00 - 13:00

Location:Room B106, Lui Che Woo Building

Abstract


The idea of "Cancer Evolution" has revolutionize cancer research, pharmacy and clinics. Contrary to the traditional understanding of cancer tissue and metastatic process, tumor composition and structure, which were only able to be detailed depicted by, show high intratumorheterogeneity, fostering tumor evolution during metastasis. As an analogy of ecological systems, tumor tissues exhibit some complicated behaviors such as speciation, competition and cooperation, which elicit innovative ideas of trial design targeted at tumor evolution. Clarifying the diversity and interaction of tumor cells systematically is a key step towards more efficacious and precise cancer therapy. 

In this JC, we will firstly give a brief introduction of development of this idea, 'Cancer Evolution', the possible relation between intratumor heterogeneity and drug resistance, and the history of TRACERx.
Then we will focus on the work of TRACERx, ranging, including experimental design, implicated technique, and data analysis, to show how tumor evolution was elucidated in spite of tons of challenges.
Finally, we will talk about how computational modeling facilitated the study in this field and what we can expect in the coming future.





Guest information:

1. Dr. Xiaojing Yang (PKU)

http://www.aais.pku.edu.cn/duiwu/showproduct.php?id=176



Recommend Literatures:
Review:

1. McGranahan, Nicholas, and Charles Swanton. "Clonal heterogeneity and tumor evolution: past, present, and the future." Cell 168.4 (2017): 613-628.

Link: https://doi.org/10.1016/j.cell.2017.01.018


Papers:

1. Abbosh, Christopher, et al. "Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution." Nature 545.7655 (2017): 446.

Link: https://www.nature.com/articles/nature22364?sf73618832\u003d1

2. Jamal-Hanjani, Mariam, et al. "Tracking the evolution of non–small-cell lung cancer." New England Journal of Medicine376.22 (2017): 2109-2121.

DOI: 10.1056/NEJMoa1616288