Journal Club | Intratumor Heterogeneity and Cancer EvolutionMay.19.2019
Speaker：Siya Xie（谢思雅）Yuxiang Huang（黄宇翔）Wenbin Mei（梅文彬）Wei Lu（卢巍）
Time：10:00 - 13:00
Location：Room B106, Lui Che Woo Building
The idea of "Cancer Evolution" has revolutionize cancer research, pharmacy and clinics. Contrary to the traditional understanding of cancer tissue and metastatic process, tumor composition and structure, which were only able to be detailed depicted by, show high intratumorheterogeneity, fostering tumor evolution during metastasis. As an analogy of ecological systems, tumor tissues exhibit some complicated behaviors such as speciation, competition and cooperation, which elicit innovative ideas of trial design targeted at tumor evolution. Clarifying the diversity and interaction of tumor cells systematically is a key step towards more efficacious and precise cancer therapy.
1. Dr. Xiaojing Yang (PKU)
1. McGranahan, Nicholas, and Charles Swanton. "Clonal heterogeneity and tumor evolution: past, present, and the future." Cell 168.4 (2017): 613-628.
1. Abbosh, Christopher, et al. "Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution." Nature 545.7655 (2017): 446.
2. Jamal-Hanjani, Mariam, et al. "Tracking the evolution of non–small-cell lung cancer." New England Journal of Medicine376.22 (2017): 2109-2121.