Journal Club | Theories cells use in playing a game: cell competition during developmentMay.11.2019
Speaker：Yuchun Wang（王雨纯）Ziqi Dong（董梓琪）Xiaoyi Ouyang（欧阳筱羿）Meichen Fang（方美琛）Junxiao Hou（侯郡潇）
Time：10:00 - 13:00
Location：Room B106, Lui Che Woo Building
Contrary to the view that the developmental process is intrinsically determined and precisely regulated, cell competition is widely existing. By cell competition, less fit cells are eliminated while more fit cells get the chance to expand their clones. Although the molecular basis to distinguish such difference has been identified such as Myc heterogeneity and apico-basal cell polarity, the molecular mechanism and precise process remain to be poorly understood. More importantly, cell competition is very common during tissue regeneration and tumorigenesis, emphasizing the importance to investigate such process. Also, such cell competition is also related to other essential cellular process such as quality control systems. Here, I choose two research paper about this topic. One is about dissecting the signaling involved in the competition and how it is related to immune response, and another is the work to look close to see how winner cells expand them to compensate for the space the loser cells leaves.
1. Dr. Yan Song(PKU)
1. Madan, Esha, Rajan Gogna, and Eduardo Moreno. "Cell competition in development: information from flies and vertebrates." Current opinion in cell biology 55 (2018): 150-157.
1. Rhiner, Christa, et al. "Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila." Developmental cell 18.6 (2010): 985-998.
2. Clavería, Cristina, et al. "Myc-driven endogenous cell competition in the early mammalian embryo." Nature500.7460 (2013): 39.