Events
Journal Club | Bacteria Act on Your Nerves
Mar.23.2019Speaker：Xiaozhou Ye（叶小洲）Youran Yang（杨悠然）Xingyu Ru（茹星语）
Time：10:00 - 13:00
Location：Room 348, Wangkezhen Building
Abstract:
Can microorganisms influence our nervous system? In host–pathogen interactions, bacterial pathogens produce pain by directly activating sensory neurons that modulate inflammation. Microbial metabolites could influence microglia and astrocytes in the CNS thus modulate inflammation and neurodegeneration in nervous system. These findings inspire us to form deeper understand of the relationship between pathogen/microbiota, neuron system and immune system in Physiology.
Guest information:
1. Dr. Miao Jinghttp://www.cibr.ac.cn/index.php?s=/Show/index/cid/16/id/24.html
Review:
1. Sharon, G., Sampson, T.R., Geschwind, D.H., Mazmanian, S.K., 2016. The Central Nervous System and the Gut Microbiome. Cell 167, 915–932.
Link: https://doi.org/10.1016/j.cell.2016.10.027
2. Mayer, E.A., Knight, R., Mazmanian, S.K., Cryan, J.F., Tillisch, K., 2014. Gut Microbes and the Brain: Paradigm Shift in Neuroscience. Journal of Neuroscience 34, 15490–15496.
Link: https://doi.org/10.1523/JNEUROSCI.3299-14.2014
Papers:1. Sampson, T.R., Debelius, J.W., Thron, T., Janssen, S., Shastri, G.G., Ilhan, Z.E., Challis, C., Schretter, C.E., Rocha, S., Gradinaru, V., Chesselet, M.-F., Keshavarzian, A., Shannon, K.M., Krajmalnik-Brown, R., Wittung-Stafshede, P., Knight, R., Mazmanian, S.K., 2016. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell 167, 1469-1480.e12.
Link: https://doi.org/10.1016/j.cell.2016.11.018
2. Pinho-Ribeiro, F.A., Baddal, B., Haarsma, R., O’Seaghdha, M., Yang, N.J., Blake, K.J., Portley, M., Verri, W.A., Dale, J.B., Wessels, M.R., Chiu, I.M., 2018. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell 173, 1083-1097.e22.
