Speaker：Jinyi Han（韩瑾仪）Can Liu（刘灿）Zhetao Zheng（郑哲涛）

Time：10:00 - 13:00

Over the past decades, despite our progress in understanding and treatment of cancer, many drugs that performed well in mouse models failed in clinical trials, and some patients responded to specific treatments not as well as others. Part of the reason lies in that many cancer models only poorly recapitulate the patients’ tumor, which has led to the need of cancer models that are convenient to get and mimic the tumor faithfully. In recently developed 3D culture technologies, tissue-derived stem cells can grow into self-organizing organotypic structures termed “organoids”, which allow for a wide range of applications in cancer research. We will discuss how long-term organoid cultures can be established from tissues, how organoids help understand the mutational processes underlying tumorigenesis, and how they recapitulate patients’ drug responses in the clinic.

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Link: https://www.nature.com/articles/nrd.2015.21

2. Vlachogiannis, Georgios, et al. "Patient-derived organoids model treatment response of metastatic gastrointestinal cancers." Science 359.6378 (2018): 920-926.

Link: http://science.sciencemag.org/content/359/6378/920.abstract