Events
Journal Club | Talk between DNA damage response and immune response
Dec.09.2018Speaker：魏琦佳。2015级生命科学学院的王依琛、李子涵、2017级基础医学院临床专业的王泽怡
Time：10:00 - 13:00
Location：Room 348, Kezhen Wang Building
Abstract:The characteristic feature of healthy living organisms is the preservation of homeostasis. The DNA damage response and immune response are both established responses that promotes homeostasis. However, research on them are relatively independent. The cGAS-STING signaling pathway is a component of the innate immune system. It is critical for the celluar immune response to pathogen-derived cytosolic double-stranded DNA. Increasing evidence suggests that genomic DNA damage leads to cGAS activation to stimulate inflammatory responses. Micronuclei, which are small, DNA-containing organelle produced under genotoxic stress or during cell division, has gained increasing attention since its connection with cGAS corroborates the interlink between the two responses. These findings suggest that cGAS-STING is a therapeutic target in cancer.
Guest information:
1. Dr. Fuping You (PKU)
http://sbms.bjmu.edu.cn/jsdw/bssds/dsjs/132521.htm
2. Dr. Jian Zhu (PKU)
http://cls.pku.edu.cn:8080/index.php?m=content&c=index&a=show&catid=81&id=58
3. Juyi Gao (Graduate student)
4. Chenguang Wang (Graduate student)
Review:
1. Z.J. Chen, et al. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. J Exp Med, 2018, 215: 1287.
Papers:
1. K.J.Mackenzie, et al., cGAS surveillance of micronuclei links genome instability to innate immunity. Nature, 2017, 548: 461.
2. S.L.Berger, et al. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature, 2017, 550: 402.
