Speaker：Minming Wang（王闽铭）Ziqi Dong（董梓琪）Xiaohe Xie（谢霄鹤）Zhou Zhu（朱舟）

Time：10:00 - 13:00

Abstract:

Excess dietary lipid uptake causes obesity, a major global health problem that bothers lots of people. Recently, some scientists came up with a cleaver idea to solve this problem from the source forward. Dietary fats are absorbed by enterocytes and incorporated into triglyceride-rich lipoproteins, called chylomicrons. Nearly all dietary lipids are transported in chylomicrons from the intestine to tissues via the lymphatic system. Through inducible endothelial genetic deletion, they prevent lacteal chylomicron uptake by “zippering up the lacteal junction”, which rendered mice resistant to diet-induced obesity. These data suggest that lacteal junctions may be a potent target for preventing dietary fat uptake.

Guest information:

2. Dr. Yifu Qiu (PKU)

http://www.cls.edu.cn/PrincipalInvestigator/pi/index2877.shtml

1. Zhang, Feng, et al. "Lacteal junction zippering protects against diet-induced obesity." Science 361.6402 (2018): 599-603.

2. Schulte-Merker, Stefan, Amélie Sabine, and Tatiana V. Petrova. "Lymphatic vascular morphogenesis in development, physiology, and disease." The Journal of cell biology 193.4 (2011): 607-618.