Speaker：Jingliang Zhang（张景亮）Yanli Zhang（张燕丽）Jingye Wang（王敬业）

Time：10:00 - 13:00

Location：Room 348, Kezhen Wang Building

Abstract:

Aging is the gradual loss of molecular fidelity after reaching sexual maturity, culminating in loss of function and ultimately in disease and death. In most organisms, the rate of aging is inversely proportional to mean lifespan. Increased age is also the largest risk factor for cancer, neurodegeneration and cardiovascular disease. On the other hand, healthspan is defined as the duration of time for which an organism remains free of chronic disease. Identifying ways to increase lifespan and healthspan are intriguing areas of biogerontology research. And in recent years, accumulating evidence linking aging to genetic and epigenetic alterations is found. That will be a potential key to cure age-related disease.

http://www.aais.pku.edu.cn/en/duiwu/showproduct.php?lang=cn&id=169

http://www.bio.pku.edu.cn/teacher_dis_oa.php?cid=208&&teaid=61

3. Dr. Yang Zhao (PKU)

http://www.cls.edu.cn/PrincipalInvestigator/pi/index3730.shtml

4. Dr. Qiwei Zhang (THU)

http://bioinfo.au.tsinghua.edu.cn/member/mzhang/

Benayoun B A, Pollina E A, Brunet A. Epigenetic regulation of ageing: linking environmental inputs to genomic stability[J]. Nature Reviews Molecular Cell Biology, 2015, 16(10):593-610.

DOI: 10.1038/nrm4048.

2. Sun D, et al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.[J]. Cell Stem Cell, 2014, 14(5):673-688.

DOI: 10.1016/j.stem.2014.03.002.