Speaker：Anqi Yu（于安琪）Jiashu Shen（申嘉澍）Wanzhuo He（贺婉卓）

Time：10:00 - 13:00

Location：Room 311, Kezhen Wang Building

To ensure sufficient supply of oxygen and nutrients, the heart develops a complex coronary vasculature system. Although many principles of angiogenesis, especially tumor related vessel formation, have been unveiled in the past several decades, the cellular origins and development program of coronary arteries still mostly remain elusive. Coronary artery disease and its sequelae, like myocardial infarction and heart arrest, takes away millions of lives each year, making it the leading cause of death. Elucidating mechanisms of coronary artery development could not only further our understanding of such diseases, but lead to promising treatment stimulating heart revascularization and regeneration, instead of grafts and coronary bypass surgery. 

1. Aibin He (PKU)

http://www.cls.edu.cn/PrincipalInvestigator/pi/index2203.shtml

Tian, X., Pu, W. T., & Zhou, B. (2015). Cellular origin and developmental program of coronary angiogenesis. Circulation Research, 116(3), 515.

Link: https://www.ahajournals.org/doi/abs/10.1161/circresaha.116.305097

1. Redhorse, K., Ueno, H., Weissman, I. L., & Krasnow, M. A. (2010). Coronary arteries form by developmental reprogramming of venous cells. Nature, 464(7288), 549-553.

DOI: 10.1038/nature08873

2. Wu, B., Zhang, Z., Lui, W., Chen, X., Wang, Y., & Chamberlain, A. A., et al. (2012). Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial vegf signaling. Cell, 151(5), 1083-1096. 

DOI: 10.1016/j.cell.2012.10.023.