Committee

Chenjian Li

E-mail : li_chenjian@pku.edu.cn

Job title :
Professor

EDUCATION EXPERIENCE

1997, Purdue University, Neuroscience and Physiology, Ph. D.
1987-1988, Peking Union Medical College
1984-1987 School of Life Science, Peking University, Pre-Med Class.

WORK EXPERIENCE

2016-2018, Yuanpei College, Peking University, vice president;
2012- School of Life Science, Peking University, Professor;
2010- Mount Sinai School of Medicine, New York University, Lecture Professor
2009-2010 Cornell University, Vice Professor
2003-2009 Cornell University, Associate Professor
1997-2003 Rockefeller University, Post-doc

RESEARCH DESCRIPTION

2016-2018, Yuanpei College, Peking University, vice president;
2012- School of Life Science, Peking University, Professor;
2010- Mount Sinai School of Medicine, New York University, Lecture Professor
2009-2010 Cornell University, Vice Professor
2003-2009 Cornell University, Associate Professor
1997-2003 Rockefeller University, Post-doc

SELECTED PUBLICATIONS

1. Zheng, S.,Geghman, K., Shenoy, S., Li, C , Retake the Center Stage - New Development of Rat Genetics. , Journal of Genetics and Genomics. , 2012 , 39(6):261-8.　　
2. Yong Huang and Chenjian Li , Proteasome dysfunction in animal models for PINK1 Parkinson’s disease , J Neurogenetics , 2012 , 26(2):158-67　　
3. Qing Xu, Sushila Shenoy and Chenjian Li , Mouse Models for LRRk2 Parkinson’s Disease , Parkinsonism and Related Disorders , 2012 , 18, 186-189.　　
4. Dagda R, Gusdon A, Pien I, Strack S, C Li, Cherra J, and Chu C. , Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease. , Cell Death and Differentiation. , 2011 , 18, 1914-1923.　　
5. Kindiya Geghman and Chenjian Li , ractical consideration of genetic rodent models for neurodegenerative disease. , Methods in Mol Biol. , 2011 , 793:185-193.　　
6. Wencheng Liu, Rebeca Acin-Perez, Kindiya Geghman, Giovanni Manfredi, Bing Wei Lu and Chenjian Li , Pink1 regulates the assembly of oxidative phosphorylation machinery via mitochondrial fission , Proc Natl Acad Sci.USA. , 2011 , 108, 12920-12924.　　
7. Cristofol Vives-Bauza, Chun Zhou, Yong Huang, VAlina Dawson, Darren More, Grailhe, Ted Dawson, Chenjian Li, Serge Przedborski. , PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. , Proc Natl Acad Sci. USA. , 2010 , 107, 378-383.　　
8. Wencheng Liu, Cristofol Vives-Bauza, Rebeca Acin-Perez, Ai Yamamoto, Yingcai Tan, Yanping Li, Jordi Magrane, , Mihaela Stavarache, Michael Kaplitt, Xin-Yun Huang, M. Flint Beal, Giovanni Manfredi and Chenjian Li , Mutant PINK1 causes mitochondrial dysfunction, proteasomal deficit and α-synuclein aggregation in Parkinson’s disease models. , PLoS ONE. , 2009 , 4(2): e4597.　　
9. Yanping Li, Wencheng Liu, Tinmarlar F. Oo, Lei Wang, Yi Tang, Vernice Jackson-Lewis, Chun Zhou, Kindiya Geghman, Serge Przedborski, M.Flint Beal Robert Burke and Chenjian Li , BAC transgenic mouse model for LRRK2 recapitulates robust Parkinson’s disease phenotypes. , Nature Neuroscience. , 2009 , 12, 826-828.　　
10. Younghwa Kim, Ping Zhou, Liping Qian, Jesica Lee, Chenjian Li, Constantino Iadecola, Carl Nathan and Aihao Ding. , MyD88-5 links mitochondra, microtubules and JNK3 in Neurons and regulates Neuronal survival. , J. Exp Medicine (Cover). , 2007 , 204(9):2063-74.　　
11. Chenjian Li and M Flint Beal. , Leucine-rich repeat kinase 2: a New player with a familiar theme for Parkinson’s disease pathogenesis. , Proc Natl Acad Sci. USA. , 2005 , 102, 16535-16537.　　
12. Tsu-kang Sang, Chenjian Li, Lawrence Zipursky, George Jackson. , Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. , Hum Mol Genet. , 2005 , 14(3):357-72　　
13. Xiaofeng Gu, Chenjian Li, Weicheng Wei, Victor Lo, Shiaoching Gong, Shihua Li, TAkuji Iwasato, Shigeyoshi Itohara, XiaoJiang Li, Istvan Mody, Nathaniel Heintz, William Yang, , Pathological cell-cell interactions elicited by a neuropathogenic form of mutant huntingtin contribute to cortical pathogenesis in HD mice. , Neuron. , 2005 , 46, 433-444.　　
14. Chenjian Li, Wayne Brake, Russell Romeo, Marisa Gordon, Rodica Buzescu, Patrick Allen, Paul Greengard, Bruce McEwen , Hippocampal neuron dendritic spine maturation, synaptic proteins immunoreactivity and performance in spatial learning tasks in mice. , Proc Natl Acad Sci.USA. , 2004 , 101, 2185-90.　　
15. Shaoching Gong, William Yang, Chenjian Li, Nathaniel Heintz , Highly Efficient Modification of Bacterial Artificial Chromosomes (BACs) Using Novel Shuttle Vectors Containing the R6Kr Origin of Replication. , Genome Research. , 2002 , 12:1992-1998.　　
16. Bruce McEwen, Keith Akama, Steve Alves, Wayne Brake, Chenjian Li, Yuen G , Tracking the estrogen receptor in neurons: implications for estrogen-induced synapse formation. , Proc Natl Acad Sci USA. , 2001 , 98:7093-7100.　　
17. Milner, T. A., McEwen, B. S., Hayashi, S., Chenjian Li, Reagan, L. P., Alves, S. E. , Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. , J Comp Neurol. , 2001 , 429(3)355-371.　　
18. Chenjian Li, Chaoxian Geng, Hung-Tat Leung, Young Seok Hong, Lydia R. Strong, William L. Pak. , InaF, a Protein Required For Transient Receptor Potential Ca2+ Channel Function. , Proc Natl Acad Sci.USA. , 1999 , 96(23):13474-13479.

LABORATORY INTRODUCTION

The Li Laboratory is a leading group for inventing genetic methods in transgenic mouse and rats, and has used these methods to establish some of the animal models that are most commonly used by academic labs and pharmaceutical industry in neurodegeneration field. These animal models are powerful tools for mechanistic studies as well as drug discoveries. We are also developing transgenic method for non-human primates, Rhesus monkey as the next generation tools.