Committee

Hongkui Deng

E-mail : hongkui_deng@pku.edu.cn

Job title :
Professor

Office Address : Jinguang Life Science Building,Peking University, No.5 Yiheyuan Road, Haidian District,Beijing, P.R.China

Laboratory home page : http://www.bio.pku.edu.cn/teacher_dis_oa.php?cid=146&&teaid=16

SELECTED PUBLICATIONS

1. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, Xu Y, Dong J, Wang C, Lai W, Zhu J, Xiong L, Zhu D, Li X, Yang W, Yamauchi T, Sugawara A, Li Z, Sun F, Li X, Li C, He A, Du Y, Wang T, Zhao C, Li H, Chi X, Zhang H, Liu Y, Li C, Duo S, Yin M, Shen H, Belmonte JC, Deng H. Cell. 2017; 169(2):243-257.

2. Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Li X, Liu D, Ma Y, Du X, Jing J, Wang L, Xie B, Sun D, Sun S, Jin X, Zhang X, Zhao T, Guan J, Yi Z, Lai W, Zheng P, Huang Z, Chang Y, Chai Z, Xu J, Deng H. Cell Stem Cell. 2017;21(2):264-273.

3. CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo. Xu L, Yang H, Gao Y, Chen Z, Xie L, Liu Y, Liu Y, Wang X, Li H, Lai W, He Y, Yao A, Ma L, Shao Y, Zhang B, Wang C, Chen H, Deng H. Mol Ther. 2017;25(8):1782-1789.

4. Zhao Y, Zhao T, Guan J, Zhang X, Fu Y, Ye J, Zhu J, Meng G, Ge J, Yang S, Cheng L, Du Y, Zhao C, Wang T, Su L, Yang W, Deng H. A XEN-like State Bridges Somatic Cells to Pluripotency during Chemical Reprogramming. Cell, 2015, 163, 1678-91.

5. Li X, Zuo X, Jing J, Ma Y, Wang J, Liu D, Zhu J, Du X, Xiong L, Du Y, Xu J, Xiao X, Wang J, Chai Z, Zhao Y, Deng H. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015, 17:195-203.

6. Xu J, Du Y, Deng H. Direct lineage reprogramming: strategies, mechanisms, and applications. Cell Stem Cell. 2015, 16(2):119-34. Review

7. Fang R, Liu K, Zhao Y, Li H, Zhu D, Du Y, Xiang C, Li X, Liu H, Miao Z, Zhang X, Shi Y, Yang W, Xu J, Deng H. Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts. Cell Stem Cell. 2014; 15(4):488-96.

8. Du Y, Wang J, Jia J, Song N3 Xiang C, Xu J, Hou Z, Su X, Liu B, Jiang T, Zhao D, Sun Y, Shu J, Guo Q, Yin M, Sun D, Lu S, Shi Y, Deng H , Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming , Cell Stem Cell , 2014 , 14:3 94-403　　

9. Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, Zhao T, Ye J, Yang W, Liu K, Ge J, Xu J, Zhang Q, Zhao Y, Deng H. , Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds , Science , 2013 , 341(6146): 651-4.

10. Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C, Zhao Y, Deng H , Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell, 2013, 153(5): 963-75　　

11. Sun X, Xu J, Lu H, Liu W, Miao Z, Sui X, Liu H, Su L, Du W, He Q, Chen F, Shi Y, Deng H. , Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo , Cell Stem Cell , 2013, 13(2): 230-6　　

12. Zhao D, Chen S, Duo S, Xiang C, Jia J, Guo M, Lai W, Lu S, Deng H , Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects , Cell Research , 2013 , 23(1): 157-61　　

13. Wang C, Tang X, Sun X, Miao Z, Lv Y, Yang Y, Zhang H, Zhang P, Liu Y, Du L, Gao Y, Yin M, Ding M, Deng H , TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy , Cell Research , 2012 , 22(1): 194-207　　

14. Li Y, Zhang Q, Yin X, Yang W, Du Y, Hou P, Ge J, Liu C, Zhang W, Zhang X, Wu Y, Li H, Liu K, Wu C, Song Z, Zhao Y, Shi Y, Deng H. Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res. 2011, 21(1):196-204.　　

15. Yu C, Liu Y, Miao Z, Yin M, Lu W, Lv Y, Ding M, Deng H. Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors, Blood. 2010, 116(23):4786-94.

16. Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H and Ding S , Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors , Cell Stem Cell , 2009 , 4(1):16-9.

17. Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res. 2009, 19(4):429-38.

18. Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H , Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts , Cell Stem Cell , 2008 , 3(6):587-90.

19. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H , Two supporting factors greatly improve the efficiency of human iPSC generation , Cell Stem Cell , 2008 , 3(5):475-9.　　

20. Zhang P, Li J, Wang C, Tan Z, Liu T, Chen L, Yong J, Jiang W, Sun X, Ding M, Deng H, , Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood, 2008, 111(4): 1933-41.　　

21. Wang C, Faloon P, Tan Z, Lv Y. Zhang P, Deng H, Xiong J. Mouse Lycat Controls the Development of Hematopoietic and Endothelial Lineages during in vitro ES Cell Differentiation. Blood, 2007, 110(10): 3601-9.

22. Cai J, Zhao Y, Ye F, Liu Y, Song Zhi, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M, Deng H, , Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology, 2007, 45(5): 1229-1239.
　　
23. Jiang W, Shi Y, Zhao D, Chen S, Yong J, Zhang J, Qing T, Sun X, Zhang P, Ding M and Deng H. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res. 2007, 17(4):333-44.

24. Shi Y, Hou L, Tang F, Jiang W, Wang P, Ding M, Deng H. Inducing Embryonic Stem Cells to Differentiate into Pancreatic Beta Cells by a Novel Three-Step Approach with Activin A and All-Trans Retinoic Acid. Stem Cells, 2005, 23(5): 656-62. 52.　　

25. Deng H, Unutmaz D, Kewalramani V, Littman D. Expression cloning of novel coreceptors utilized by the simion and human immunodeficency viruses , Nature, 1997, 388:296-300.
　　
26. Deng H, Liu R, Ellmeier W, Choe S, Untmaz D, Burkhart M, Marazio P, Marmon S, Sutton R., Hill C, Davis C, Peiper S, Schall T, Littman D, Landau N , Identification of a major co-receptor for primary isolates HIV-1 , Nature, 1996, 381:661-666.