Advisors
Alan Jian Zhu
E-mail : zhua@pku.edu.cn
Job title :
Investigator
Office Address : Jinguang Building, Peking University, Yiheyuan Road No.5, Haidian District, Beijing
EDUCATION EXPERIENCE
2000 - 2005, Postdoctoral training, Developmental Biology, Stanford University School of Medicine, USA
1994 - 1999, Ph.D, Molecular Cell Biology, Imperial Cancer Research Fund / Imperial College London, UK
1990 - 1994, BSc. (Honours), Biochemistry, University of Aberdeen, UK
WORK EXPERIENCE
2013 - present, Investigator, Peking University - Tsinghua University Center for Life Sciences
2013 - present, Investigator, School of Life Sciences, Peking University
2006 - 2013, Assistant Professor and Associate professor (from 2013), Cleveland Clinic Lerner Research Institute / Case Western Reserve University School of Medicine
RESEARCH DESCRIPTION
2013 - present, Investigator, Peking University - Tsinghua University Center for Life Sciences
2013 - present, Investigator, School of Life Sciences, Peking University
2006 - 2013, Assistant Professor and Associate professor (from 2013), Cleveland Clinic Lerner Research Institute / Case Western Reserve University School of Medicine
SELECTED PUBLICATIONS
1. Wang, L. C., Liao, L. X.,, Lv, H.N., Liu, D., Dong, W., Zhu, A. J., Chen, J. F., Shi, M. L., Fu, G., Song, X. M., Jiang, Y., Zeng, K. W. and Tu, P. F. (2017) Highly selective activation of heat shock protein 70 by allosteric regulation provides an insight into efficient neuroinflammation inhibition. EBioMedicine, 23: 160-172.
2. Du, J., Zhang, J., He, T., Li, Y., Su, Y., Tie, F., Liu, M., Harte, P. J. and Zhu. A. J. (2016) Stuxnet facilitates the degradation of Polycomb protein during development. Developmental Cell, 37: 507-519 (Cover featured article).
Commented in Developmental Cell, Science China Life Sciences, and F1000Prime.
Karch, F. (2016) Stuxnet recruits the proteasome to take down Polycomb. Developmental Cell, 37: 485-486.
Wu, X. (2016) Stuxnet detected, Pc breaks down. Science China Life Sciences, 59:1202-1203.
3. Liu, M., Li, Y., Liu, A., Li, R., Su, Y., Du, J., Li, C. and Zhu, A. J. (2016) The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development. eLife, 5: e17200.
4. Zhang, J., Du, J., Lei, C., Liu, M. and Zhu, A. J. (2014) UBPY controls the stability of the ESCRT-0 subunit Hrs in development. Development, 141: 1473-1479.
5. Geisbrecht, E. R., Sawant, K., Su, Y., Liu, Z., Silver, D. L., Burtscher, A., Wang, X., Zhu, A. J. and McDonald J. A. (2013) Genetic interaction screens identify a role for Hedgehog signaling in Drosophila border cell migration. Developmental Dynamics, 242: 414-431.
6. Zhang, J., Liu, M., Su, Y., Du, J. and Zhu, A. J. (2012) A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. G3 Genes Genomes Genetics, 2: 1563-1575 (Cover featured article).
7. Su, Y., Ospina, J. K., Zhang, J., Michelson, A., Schoen, A. M. and Zhu, A. J. (2011) Sequential phosphorylation of Smoothened transduces graded Hedgehog signaling. Science Signaling, 4: ra43.
Commented in Science Signaling.
VanHook, A. M. (2011) Fine-tuning Hedgehog signaling in development and disease. Science Signaling, 4: eg10.
8. Du, J., Zhang, J., Su, Y., Liu, M., Ospina, .J. K., Yang, S. and Zhu, A. J. (2011) In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling. PLoS ONE, 6: e2416.
9. Huang X., Suyama, K., Buchanan, J., Zhu, A. J. and Scott, M. P. (2005) A Drosophila Model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Development, 132: 5115-5124.
10. Zhu, A. J. and Scott, M. P. (2004) Incredible journey: How do developmental signals travel through tissue? Genes & Development, 18: 2985-2997 (Cover featured article).
11. Hwa, J. J.,* Zhu, A. J.,* Hiller, M. A., Kon, C. Y., Fuller, M. T., Santel, A. (2004) Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila. FEBS Letter, 572: 141-146 (* Co-first author).
12. Zhu, A. J., Zheng, L., Suyama, K. and Scott, M. P. (2003) Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes & Development, 17: 1240-1252 (Cover featured article).
Commented in Current Biology, and F1000Prime.
van den Heuvel, M. (2003) Hedgehog signaling: off the shelf modulation. Current Biology, 13: R686-R688.
13. Zhu, A. J. and Watt, F. M. (1999) β-Catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development, 126: 2285-2298.
14. Zhu, A. J., Haase, I. and Watt, F. M. (1999) Signaling via β1 integrins and mitogen-activated kinase determines human epidermal stem cell fate in vitro. Proceedings of National Academy of Sciences of the United States of America, 96: 6728-6733.
15. Zhu, A. J. and Watt, F. M. (1996) Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes, Journal of Cell Science, 109: 3013-3023.
COACHING CURRICULUM
CLS Graduate Program Fundamental Developmental Biology track Organizer, Fall semester
CLS Graduate Program Advanced Developmental Biology track Organizer, Fall semester
PTN Graduate Program Developmental Biology track, Participant, Spring semester
Undergraduate Developmental Biology course, Organizer, Spring semester
