Advisors
Junyu Xiao
E-mail : junyuxiao@pku.edu.cn
Job title :
Investigator
Office Address : Jinguang Life Science Building,Peking University, No.5 Yiheyuan Road, Haidian District, Beijing
EDUCATION EXPERIENCE
2003 - 2008 , Ph.D. , Biological Chemistry , University of Michigan
1998 - 2002 , B.S. , Biochemistry and Molecular Biology , Peking University
WORK EXPERIENCE
2014- Assistant Professor/Principle Investigator , Peking University
2011-2013 Assistant Project Scientist , University of California, San Diego
2009-2011 Postdoctoral Scholar, Pharmacology , University of California, San Diego
RESEARCH DESCRIPTION
2014- Assistant Professor/Principle Investigator , Peking University
2011-2013 Assistant Project Scientist , University of California, San Diego
2009-2011 Postdoctoral Scholar, Pharmacology , University of California, San Diego
SELECTED PUBLICATIONS
1. Xiao, J., Tagliabracci, V. S., Wen, J., Kim, S. A., and Dixon, J. E. (2013). Crystal Structure of the Golgi Casein Kinase. Proc. Natl. Acad. Sci. U S A. 110(26):10574-9.
2. Xiao, J., Engel, J. L., Zhang, J., Chen, M. J., Manning, G., and Dixon, J. E. (2011). Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc. Natl. Acad. Sci. U S A. 108(29):11860-5.
3. Xiao, J., Worby, C. A., Mattoo, S., Sankaran, B., and Dixon, J. E. (2010) Structural basis of Fic mediated adenylylation. Nature Structural and Molecular Biology. 17(8):1004-10.
4. Xiao, J., Chen, X. W., Davies, B. A., Saltiel, A. R., Katzmann, D. J., and Xu, Z. (2009) Structural basis of Ist1 function and Ist1-Did2 interaction in the MVB pathway and cytokinesis. Molecular Biology of the Cell. 20(15):3514-24.
5. Xiao, J., Xia, H., Zhou, J., Azmi, I., Davies, B. A., Katzmann, D. J., and Xu, Z. (2008) Structural basis of Vta1 function in the multi-vesicular body sorting pathway. Developmental Cell. 14(1):37-49.
6. Xiao, J., Xia, H., Yoshino-Koh, K., Zhou, J., and Xu, Z. (2007) Structural Characterization of the ATPase Reaction Cycle of Endosomal AAA-Protein Vps4. J Mol Biol. 374(3):655-70.
7. Tagliabracci, V. S.#, Xiao, J.#, and Dixon, J. E. (2013) Phosphorylation of Substrates Destined for Secretion by the Fam20 Kinases. Biochem Soc Trans. 41(4):1061-5. (# Equal contribution).
8. Cui, J., Xiao, J., Tagliabracci, V. S., Wen, J., Rahdar, M., and Dixon, J. E. (2015) A secretory kinase complex regulates extracellular protein phosphorylation. Elife. 4, e06120.
9. Wen, J., Xiao, J., Rahdar, M., Choudhury, B. P., Cui, J., Taylor, G. S., Esko, J. D., and Dixon, J. E. (2014) Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc. Natl. Acad. Sci. U S A. 111(44):15723-8.
COACHING CURRICULUM
Biochemistry
Structural Biology
LABORATORY INTRODUCTION
Research aspects:
1.Secretory Pathway Kinases
2.Cellular Signaling
3.Structural Biology
