2019 Annual Symposium
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KEYNOTE LECTURE
Endocytic Recycling Pathway Determines the Properties of Neurotransmitter Release
Robert Edwards
Professor of Neurology and Physiology University of California, San Francisco School of Medicine
Abstract：
In the course of studying glutamate corelease by dopamine neurons, we
found that the two transmitters signal with different short-term kinetics:
the glutamate response depresses more rapidly than the dopamine.
Although this might reflect differences in the properties of glutamate
and dopamine receptors, we found that release of the two transmitters
couples to different presynaptic Ca2+ channels. The direct analysis of
individual release events by imaging shows that vesicles storing
glutamate and dopamine behave differently even when located at the
same presynaptic bouton. The two synaptic vesicle populations also
appear to form through different endocytic mechanisms. In contrast to
glutamate vesicles which have been shown to recycle dependent on
clathrin and its adaptor protein AP-2, monoamine vesicles depend on
the related but distinct adaptor AP-3. Thus, different endocytic
pathways produce synaptic vesicles with different transmitter content
and release properties, with important implications for organization of
the nerve terminal and for the processing of information.
General Principles for Timing and Oscillations in Stochastic Reaction Systems
Johan Paulsson
Professor of System Biology
Harvard Medical School
Department of System Biology
Abstract：
Precise timing can be advantageous in many biological processes but is difficult to achieve because chemical reactions often produce exponentially distributed waiting times for individual events. I will discuss hard bounds on timing and the phase-drift of oscillators in reaction networks with finite numbers of molecules, based on analytical theory for classes of stochastic processes. Based on this theory, I then show how we designed and built a series of ultra-precise synthetic gene oscillators, some of which can oscillate for 500 cell generations without entrainment before drifting out of phase with even half a period. Finally, I will show how some natural systems use the same simple but counterintuitive principles to achieve timing in cell fate decisions, and how these are easily missed in deterministic modeling frameworks.
SESSION OVERVIEW
September 28th, 2019 (Saturday)
08:00-08:30 Registration
08:30-08:40 Opening Ceremony
08:40-12:10 Session 1
08:40-09:30 Keynote Lecture Dr. Robert Edwards
09:30-10:30 3 Student Oral Presentations
10:30-10:50 Tea Break and Photographing
10:50-12:10 4 Student Oral Presentations
12:10-14:30 Lunch and Break
14:30-18:00 Session 2
14:30-15:30 3 Student Oral Presentations
15:30-16:10 Poster Session 1 & Tea Break
16:10-17:30 4 Student Oral Presentations
17:30-18:00 Poster Session 2
18:00 Dinner
September 29th, 2019(Sunday)
08:00-08:30 Registration
08:30-08:40 Opening Ceremony
08:40-12:20 Session 3
08:40-09:30 Keynote Lecture Dr. Johan Paulsson
09:30-10:10 Poster Session 3 & Tea Break
10:10-11:30 4 Student Oral Presentations
11:30-11:50 Awards Ceremony for Best Presentations and Best Posters
11:50-12:00 Concluding Remarks
12:00-13:00 Lunch
SYMPOSIUM AGENDA
September 28th, 2019(Saturday)
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08:00-08:30 |
Registration |
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08:30-08:40 |
Opening Ceremony |
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Session 1 08:40-12:10, Youcai Deng Hall,Sinar Mars Life Science Building |
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08:40-09:30 Keynote Lecture |
Dr. Robert Edwards
UCSF, School of Medicine
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09:30-10:30 |
Student Oral Presentations Lai Wei (魏来) Promising Guidance Cues in Regulating the Development of Mammalian Aβ RAand Aδ- Low-Threshold Mechanoreceptors Tianyi Wang (王添艺) Skeletal Muscle Pathology in Huntington’s Disease BAC226Q Mouse Model Xiaowei Zhang (张晓维) Measurement of the Input Statistics of Bacteria Chemotaxis System |
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10:30-10:50 |
Tea Break and Photographing |
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10:50-12:10 |
Student Oral Presentations
Aoyue Mao (茅傲岳) Directed Evolution of GRAB Sensors Ruoxuan Zhuang (庄若璇) Structure and Function of Suppressive tRNA in the Treatment of Monogenic Genetic Diseases Yiran Wang (王一然), Fudan University Autism-risk Gene NECAB2 Regulates Psychomotor and Social Behavior through Ca2+-dependent Modulation of Type I mGluR Signaling Senhao Kou (寇森浩), Nankai University Ca2+-dependent Regulation of CBL-CIPK Complex
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12:10-14:30 |
Lunch and Break Buffet, Shao Yuan Western Restaurant |
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Session 2 14:30-18:00, Youcai Deng Hall, Sinar Mas Life Science Building |
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14:30-15:30
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Student Oral Presentations
Yuyang Chen (陈雨旸)
Explore Whether Axoneme Has Structural Twist Independent of Axonemal
Dynein Torque
Yixin Hu (胡艺馨)
Development of Genetically-Encoded Multiplex Tagsfor Cell Labeling Under
Electron Microscope
Jingyu Peng (彭靖予)
The Starvation-induced Self-inhibition Effect of E3 Ligase URX Functions in Lipid
Droplets Stability Maintenance
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15:30-16:10 |
Poster Session 1 & Tea Break |
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16:10-17:30 |
Student Oral Presentations
Zelin Wei (魏泽林) Cell Fate Determinant Guarantees Terminal Neuronal Differentiation via Phaseseparation-mediated Mitotic Implantation and Re-modelling of Heterochromatin Chenlei Hu (胡晨蕾) Localization of Phosphatase CTDNEP1 in Mammalian Cells Mingze Dong (董明泽) Quantitatively Deciphering the Regulation Pattern of Transcriptional Network in mESCs Zhou Zhu (朱舟) Identification of How PDAC Cells Cope with the Arginine Deprived Tumor Microenvironment |
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17:30-18:00 |
Poster Session 2 |
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18:00 |
Dinner |
September 29th, 2019(Sunday)
|
08:00-08:30 |
Registration |
|
08:30-08:40 |
Opening Ceremony |
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Session 3 08:40-12:20, Youcai Deng Hall, , Sinar Mas Life Science Building |
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08:40-09:30 Keynote Lecture |
Johan Paulsson, Harvard Medical School |
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09:30-10:10 |
Poster Session 3 & Tea Break |
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10:10-11:30 |
Student Oral Presentations
Jiayu Su (苏嘉昱) Transcriptional and Regulatory Landscape of Neutrophil at Single-Cell Resolution Boli Wu (吴博理) Abnormal AnkG Expression Level Leads to Deficiency of Axon Initial Segment Plasticity and Long-term Potentiation Ran Liu (刘然) PTEN/PI3K Regulate Glutamine Metabolism Qiliang Lai (赖其梁) Expression Patterns and Functional Roles of Congenital Heart Disease Risk Genes in Cardiogenesis
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11:30-11:50 |
Awards Ceremony for Best Presentations and Best Posters |
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11:50-12:00 |
Concluding Remarks |
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12:00-13:00 |
Lunch |
