Speaker：Juan Wu (武娟) Lei Zhang (张磊) Yi Zhu(朱宜) Anqi Yu (于安琪) Yangyang Sun (孙仰仰)

Time：10:00 - 13:00

Abstract:

Multipotent hematopoietic stem cell (HSC) is a very critical stem cell type which can generate nearly all the other types of hematocytes and regulate the amount of them in the blood. In vertebrate, the hematopoiesis takes place in the bone marrow from very few multipotent HSC which can self-renew and differentiate into different types of hematocytes. The transplantation of multipotent HSC has been widely used for treating hematologic diseases such as leukemia and hemophilia. In this journal club we will talk about the underlying mechanisms of the limitation and direction choice of the differentiation of multipotent HSC, and discuss how the clinical multipotent HSC transplantation treatment benefits from these researches.

Guest information:

Hanqing He (Dr. Jianwei Wang's lab, THU)

http://www.sps.tsinghua.edu.cn/cn/team/team/2016/0704/13.html

Recommend Literatures：

Review:

1. Drevon, C., and Thierry Jaffredo. "Cell interactions and cell signaling during hematopoietic development." Experimental cell research 329.2 (2014): 200-206.

Link: https://www.sciencedirect.com/science/article/pii/S0014482714004480

Papers:

1. Carrelha, Joana, et al. "Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells." Nature 554.7690 (2018): 106.

Link: https://www.nature.com/articles/nature25455

2. Bahr, Carsten, et al. "A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies." Nature (2018).

Link: https://www.nature.com/articles/nature25193