Speaker：Shangkun Wang(王尚坤） Xinyu Chen(陈心语） Boen Wang（王博恩）

Time：09:00 - 12:00

Abstract

Of fundamental interest to biologists is how organs achieve proper size and shape during development. Mechanical forces have been proposed to modulate organ growth, but a molecular mechanism that links them to growth regulation in vivo has been lacking. Here we introduce the Hippo pathway, a highly conserved signal transduction pathway that plays critical roles in diverse processes including development, homeostasis, regeneration, and diseases including cancer.

    Unlike other classical signal transduction pathways, such as EGF, TGFβ or WNT signaling pathways that react to dedicated extracellular signaling molecules, the Hippo pathway is regulated by a network of upstream components that have roles in other processes such as the establishment of cell adhesion, cell morphology, and cell polarity. We'll focus on the upstream input of the Hippo pathway that links mechanical input to development, and therapy possibilities targeting the Hippo pathway constituents.

Recommend Literatures:

Papers:

1. Rauskolb et al. (2014). Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex. Cell, 158(1), 143–156.

    2. Moya et al. (2019). Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science, 366, 1029–1034.

Reviews:

1. Zheng et al. (2019). The Hippo Signaling Pathway in Development and Disease. Developmental Cell, 50, 264-282.

    2. Moya et al. (2019). Hippo–YAP/TAZ signaling in organ regeneration and regenerative medicine. Nature Reviews, 20, 211-226