Speaker：Junhan Chang（昌珺涵）Chenlei Hu（胡晨蕾）Shuangjia Lu（鲁双嘉）Yiming Yan（燕逸铭）Yuyang Chen（陈雨旸）

Time：10:00 - 13:00

Location：Room B106, Lui Che Woo Building

Abstract

The 4D Nucleome project aims to develop and apply experimental (chromosome conformation capture approaches and super-resolution imaging) and computational approaches to map the structure and dynamics of the human and mouse genomes in space and time, find origins in genome sequences and epigenetic landscapes, with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions, such as gene expression, cell fate and cell function. 4D genome compartmentalization also varies during development, differentiation and evolution.

Guest information:

1. Dr. Cheng Li (PKU)

http://www.stat-center.pku.edu.cn/zxry/zxjy/lc/1227408.htm

2.Dr. Xiong Ji (PKU)

http://www.aais.pku.edu.cn/duiwu/showproduct.php?id=203

1. Dekker, Job, et al. "The 4D nucleome project." Nature549.7671 (2017): 219.

Link: https://www.nature.com/articles/nature23884

2. Yu, Miao, and Bing Ren. "The three-dimensional organization of mammalian genomes." Annual review of cell and developmental biology 33 (2017): 265-289.

Link: https://doi.org/10.1146/annurev-cellbio-100616-060531

1. Bintu, Bogdan, et al. "Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells." Science 362.6413 (2018): eaau1783.

DOI: 10.1126/science.aau1783

2. Sun, James H., et al. "Disease-associated short tandem repeats co-localize with chromatin domain boundaries." Cell175.1 (2018): 224-238.

Link: https://doi.org/10.1016/j.cell.2018.08.005

3. Zhang, Bin, and Peter G. Wolynes. "Topology, structures, and energy landscapes of human chromosomes." Proceedings of the National Academy of Sciences 112.19 (2015): 6062-6067.

Link: https://doi.org/10.1073/pnas.1506257112