Speaker：Jiahui Peng（彭嘉慧）Zhuoran Li（李卓然）Yuxiang Huang（黄宇翔）Ran Liu（刘然）

Time：10:00 - 13:00

Location：Room B106, Lui Che Woo Building

Abstract

Vast majority of organisms are composed of cells. In eukaryotic organisms, cells of different types vary significantly in their size, from tiny fission yeast to huge neuron cell; However, within the same type, cell size is somehow kept in good uniformity.

How does a cell of a specific cell type control its unique size? This has long been a hot field in cell biology and has been broadly studied for decades. Several mechanisms are proposed to explain how cells sense its size.  After the cell knows how big it is, if the size is not within a normal range, the cell corrects its size by mainly two approaches: through growth rate control and through cell cycle progression control.

Guest information:

1. Dr. Yiping Wang (PKU)

http://www.pepge.pku.edu.cn/index.php?s=/Index/team/cid/16/id/292.html

2. Dr. Daochun Kong (PKU)

1. Wood, Elizabeth, and Paul Nurse. "Sizing up to divide: mitotic cell-size control in fission yeast." Annual review of cell and developmental biology 31 (2015): 11-29.

Link: https://doi.org/10.1146/annurev-cellbio-100814-125601

1. Martin, Sophie G., and Martine Berthelot-Grosjean. "Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle." Nature 459.7248 (2009): 852.

Link: https://www.nature.com/articles/nature08054

2. Schmoller, Kurt M., et al. "Dilution of the cell cycle inhibitor Whi5 controls budding-yeast cell size." Nature 526.7572 (2015): 268.

Link: https://www.nature.com/articles/nature14908