Speaker：Liyuan Zhu（朱理源）Junhan Chang（昌珺涵）Renzimo Zhang（张任子墨）Ye Hong（洪烨）Xiaozhou Ye（叶小洲）

Abstract:

Liquid-liquid phase separation happens when two liquids coexist as separate phases and don’t get mixed up with each other (like oil and water). It’s proposed as an underlying mechanism of membraneless organelle formation. By phase separation, cellular space can be organized into dynamic compartments for different biological processes. In recent years many groups have jumped into this field. They came up with models or experimental evidence of how this concept can shed light on many basic questions, such as transcriptional regulation and genome organization.

Guest information:
1. Dr. Yiqin Gao (PKU)

http://old.chem.pku.edu.cn/index.php?id=382

2. Dr. Jiazhi Hu (PKU)

http://www.bio.pku.edu.cn/teacher_dis_oa.php?cid=208&&teaid=549

3. Dr. Pilong Li (THU)

http://www.cls.edu.cn/PrincipalInvestigator/pi/index2786.shtml

2. Dr. Yan Song (PKU)
http://www.bio.pku.edu.cn/teacher_dis_oa.php?cid=208&&teaid=61

Recommend Literatures：
Review:
Hyman, Anthony A., Christoph A. Weber, and Frank Jülicher. "Liquid-liquid phase separation in biology." Annual review of cell and developmental biology 30 (2014): 39-58.
DOI: https://doi.org/10.1146/annurev-cellbio-100913-013325
Papers:
1. Hnisz, Denes, et al. "A phase separation model for transcriptional control." Cell 169.1 (2017): 13-23.
DOI: https://doi.org/10.1016/j.cell.2017.02.007
2. Sabari, Benjamin R., et al. "Coactivator condensation at super-enhancers links phase separation and gene control." Science (2018): eaar3958.
Link: https://www.nature.com/articles/s41593-018-0110-8