Speaker：Yuan Fang (房苑) Jingliang Zhang (张景亮) Ziqi Dong (董梓琪)

Abstract:

Adult stem cells reside in niches that provide spatially distinct microenvironments for stem cell maintenance and function. The conceptual framework for stem cell niches, their compositions and their operating logistics is constantly being updated. For example, initially, niches were thought to be composed solely of heterologous cell populations that originate from a lineage different from the stem cells they regulate. Recent studies have added several important modifications: differentiated downstream progeny of stem cells can regulate their stem cell parents and thus become a component of the niche. Additionally, extensive studies reported the novel functions of niche. In this journal club, we are going to introduce the history and classic functions of niche in the introduction part. Then we will discuss about two ideal models for studying the interplay between stem cells and their niches. One is the hair follicle and the other one is the hematopoietic system. In the discussion, we will mainly focus on harnessing the power of niche-stem cell interactions for regeneration and disease treatment.

Guest information:

1. Dr. Feng Liu (IOZ, CAS)

http://sourcedb.cas.cn/sourcedb_ioz_cas/yw/scs/pi/200907/t20090716_2088450.html

2. Dr. Hsiang Ying Lee (PKU)

http://bio.pku.edu.cn/en/teacher_dis.php?cid=204&&teaid=602

3. Dr. Alan Jian Zhu (PKU)

http://bio.pku.edu.cn/en/teacher_dis.php?cid=204&&teaid=104

Recommend Literatures:

Review:

1. Jones D L, Wagers A J. No place like home: anatomy and function of the stem cell niche. [J]. Nature Reviews Molecular Cell Biology, 2008, 9(1):11-21.

Link: https://www.nature.com/articles/nrm2319

2. Mendelson A, Frenette P S. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. [J]. Nature Medicine, 2014, 20(8):833.

Link: https://www.nature.com/articles/nm.3647

3. Hsu Y C, Li L, Fuchs E. Emerging interactions between skin stem cells and their niches. [J]. Nature Medicine, 2014, 20(8):847.

Link: https://www.nature.com/articles/nm.3643

Papers:

1. Hsu Y C, Li L, Fuchs E. Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration [J]. Cell, 2014, 157(4):935.

Link: http://www.cell.com/cell/fulltext/S0092-8674(14)00416-4

2. Zhou B O, Yu H, Yue R, et al. Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF. [J]. Nature Cell Biology, 2017, 19(8):891-903.

Link: https://www.nature.com/articles/ncb3570