Speaker：Qiusha Huang (皇秋莎) Jiahui Peng(彭嘉慧) Yimin Jian (简依敏) Lijun Qi (齐立君)

Abstract:

Human being feel hungry when they don’t have proper food intake. The ability to form hunger perception ensures that animal would hunt for food for their survival. The neural-mechanism of hunger has been studied in the last decades. It has been reported that Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly drive hunger. It has also been shown that Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC) promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly suppressed by food-related sensory cues before ingestion. These studies may provide insights for understanding the “neuro-circuit basis” for regulation of food intake, energy expenditure and glucose homeostasis.

Guest information:

1. Dr. Yan Zhu (Institute of biophysics, Chinese Academy of Science)

http://www.ibp.cas.cn/ktzz/ktzz_Z/201308/t20130829_3920658.html

2. Dr. Yongjun Qian (Postdoc in Dr. Yi Rao’s lab, Peking University)

http://raolab.org/displaynews.php?id=144

Recommend Literatures：

Review:

1. Sternson, S.M. and A.K. Eiselt, Three Pillars for the Neural Control of Appetite. Annu Rev Physiol, 2017. 79: p. 401-423.

Link:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=27912679&query_hl=1

Papers:

1. Atasoy, D., et al., Deconstruction of a neural circuit for hunger. Nature, 2012. 488(7410): p. 172-7

Link:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=22801496&query_hl=1

2. Fenselau, H., et al., A rapidly acting glutamatergic ARC--PVH satiety circuit postsynaptically regulated by alpha-MSH. Nat Neurosci, 2017. 20(1): p. 42-51.

Link:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=27869800&query_hl=1